Association of donor T-cell chimerism with rejection and acute graft-versus-host disease
| Percent donor PB T-cell chimerism as a categorical variable . | ||
|---|---|---|
| % donor T cells on day 28 . | No. rejection/no. at risk (%) . | No. GVHD/no. at risk (%) . |
| 0-25 | 5/6 (83%) | 0/1 (0%) |
| 26-50 | 3/11 (27%) | 2/8 (25%) |
| 51-75 | 1/11 (9%) | 5/10 (50%) |
| 76-100 | 0/16 (0%) | 9/15 (63%) |
| Pvalue | .00016-150 | .326-150 |
| Percent donor PB T-cell chimerism as a categorical variable . | ||
|---|---|---|
| % donor T cells on day 28 . | No. rejection/no. at risk (%) . | No. GVHD/no. at risk (%) . |
| 0-25 | 5/6 (83%) | 0/1 (0%) |
| 26-50 | 3/11 (27%) | 2/8 (25%) |
| 51-75 | 1/11 (9%) | 5/10 (50%) |
| 76-100 | 0/16 (0%) | 9/15 (63%) |
| Pvalue | .00016-150 | .326-150 |
GVHD indicates graft-versus-host disease; PB, peripheral blood.
Analysis of GVHD restricted to 35 patients with sustained engraftment and without GVHD before day 28. Patient UL627 was excluded from analysis because of lack of DNA polymorphism.
P value obtained from Fisher's exact test.