Infection rates between day 30 and day 365 in patients given marrow compared with those given blood stem cells
| . | Marrow4-150 . | Blood4-150 . | Rate ratio for marrow/blood (95% CI) . | P . | Adjusted rate ratio (95% CI)4-151 . | P . |
|---|---|---|---|---|---|---|
| Total infections (definite and clinical) | 0.88 | 0.62 | 1.42 (1.09-1.85) | .01 | 1.48 (1.13-1.94) | .004 |
| Total definite infections | 0.68 | 0.40 | 1.70 (1.24-2.34) | .001 | 1.79 (1.29-2.47) | .0005 |
| Severe definite infections | 0.30 | 0.13 | 2.36 (1.39-4.02) | .002 | 2.46 (1.44-4.21) | .001 |
| Nonsevere definite infections | 0.38 | 0.27 | 1.39 (0.93-2.08) | .11 | 1.46 (0.97-2.21) | .07 |
| Viral infections (definite) | 0.33 | 0.23 | 1.44 (0.93-2.24) | .10 | 1.59 (1.02-2.48) | .04 |
| Bacterial infections (definite) | 0.28 | 0.16 | 1.76 (1.07-2.90) | .03 | 1.73 (1.04-2.88) | .04 |
| Fungal infections (definite) | 0.071 | 0.013 | 5.50 (1.20-25.1) | .03 | 5.55 (1.20-25.7) | .03 |
| Total clinical infections | 0.21 | 0.23 | 0.91 (0.56-1.49) | .71 | 0.94 (0.57-1.55) | .81 |
| Severe clinical infections | 0.09 | 0.08 | 1.19 (0.54-2.61) | .66 | 1.34 (0.61-2.97) | .47 |
| Nonsevere clinical infections | 0.11 | 0.15 | 0.76 (0.40-1.45) | .41 | 0.74 (0.39-1.41) | .36 |
| . | Marrow4-150 . | Blood4-150 . | Rate ratio for marrow/blood (95% CI) . | P . | Adjusted rate ratio (95% CI)4-151 . | P . |
|---|---|---|---|---|---|---|
| Total infections (definite and clinical) | 0.88 | 0.62 | 1.42 (1.09-1.85) | .01 | 1.48 (1.13-1.94) | .004 |
| Total definite infections | 0.68 | 0.40 | 1.70 (1.24-2.34) | .001 | 1.79 (1.29-2.47) | .0005 |
| Severe definite infections | 0.30 | 0.13 | 2.36 (1.39-4.02) | .002 | 2.46 (1.44-4.21) | .001 |
| Nonsevere definite infections | 0.38 | 0.27 | 1.39 (0.93-2.08) | .11 | 1.46 (0.97-2.21) | .07 |
| Viral infections (definite) | 0.33 | 0.23 | 1.44 (0.93-2.24) | .10 | 1.59 (1.02-2.48) | .04 |
| Bacterial infections (definite) | 0.28 | 0.16 | 1.76 (1.07-2.90) | .03 | 1.73 (1.04-2.88) | .04 |
| Fungal infections (definite) | 0.071 | 0.013 | 5.50 (1.20-25.1) | .03 | 5.55 (1.20-25.7) | .03 |
| Total clinical infections | 0.21 | 0.23 | 0.91 (0.56-1.49) | .71 | 0.94 (0.57-1.55) | .81 |
| Severe clinical infections | 0.09 | 0.08 | 1.19 (0.54-2.61) | .66 | 1.34 (0.61-2.97) | .47 |
| Nonsevere clinical infections | 0.11 | 0.15 | 0.76 (0.40-1.45) | .41 | 0.74 (0.39-1.41) | .36 |
CI indicates confidence interval.
Number of infections/100 patient days, ie, number of infections in all recipients of marrow or blood stem cells divided by the number of days at risk and multiplied by 100. The number of days at risk (day 30 through day 365 or the day of death or relapse) was 14 131 for recipients of marrow and 15 537 for recipients of blood stem cells.
Adjusted for pretransplantation variables known to influence the rate of posttransplantation infections, ie, donor/recipient cytomegalovirus (CMV) serostatus before transplantation (+/+, +/−, −/+, or −/−), disease/disease stage (good risk or poor risk), and splenectomy (yes or no).