Table 3.

Irradiated apoptotic leukocytes enhance allogeneic bone marrow engraftment independently of their major histocompatibility complex identity with bone marrow cells

Recipient miceFVB (H-2q)
BM cells
Irradiated SCs
(5 × 106)
Mice engrafted
(H-2q phenotype) at day
45 to day 50 post-BMT (%)3-150
BALB/c (H-2d106 None 11 (3/27) 
BALB/c (H-2d106 BALB/c (H-2d56 (14/25)3-151 
BALB/c (H-2d106 C57BL/6 (H-2b44 (11/25)3-151 
BALB/c (H-2d106 FVB (H-2q44 (15/34)3-151 
Recipient miceFVB (H-2q)
BM cells
Irradiated SCs
(5 × 106)
Mice engrafted
(H-2q phenotype) at day
45 to day 50 post-BMT (%)3-150
BALB/c (H-2d106 None 11 (3/27) 
BALB/c (H-2d106 BALB/c (H-2d56 (14/25)3-151 
BALB/c (H-2d106 C57BL/6 (H-2b44 (11/25)3-151 
BALB/c (H-2d106 FVB (H-2q44 (15/34)3-151 

BM, bone marrow; SCs, splenocytes; BMT, bone marrow transplantation.

F3-150

Pooled results of 3 independent experiments. Number of engrafted mice/number of analyzed mice at day 45 to day 50 post-BMT are indicated in parentheses.

F3-151

P < .05.

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