Table 1. Irradiated donor splenocytes... | American Society of Hematology

Table 1.

Irradiated donor splenocytes co-infused with bone marrow cells enhance allogeneic bone marrow engraftment

Recipient mice	FVB (H-2^q) BM cells	FVB (H-2^q) irradiated SCs	Mice engrafted (H-2^q phenotype) at day 45 to day 50 post-BMT (%)^*
C57BL/6 (H-2^b)	3 × 10⁵	None	3 (1/28)
	3 × 10⁵	5 × 10⁶	57 (15/26)^†
BALB/c (H-2^d)	3 × 10⁵	None	2 (1/44)
	3 × 10⁵	5 × 10⁶	38 (17/44)^†
BALB/c (H-2^d)	10⁶	None	11 (5/44)
	10⁶	5 × 10⁶	49 (25/51)^†

Recipient mice	FVB (H-2^q) BM cells	FVB (H-2^q) irradiated SCs	Mice engrafted (H-2^q phenotype) at day 45 to day 50 post-BMT (%)^*
C57BL/6 (H-2^b)	3 × 10⁵	None	3 (1/28)
	3 × 10⁵	5 × 10⁶	57 (15/26)^†
BALB/c (H-2^d)	3 × 10⁵	None	2 (1/44)
	3 × 10⁵	5 × 10⁶	38 (17/44)^†
BALB/c (H-2^d)	10⁶	None	11 (5/44)
	10⁶	5 × 10⁶	49 (25/51)^†

BM, bone marrow; SCs, splenocytes; BMT, bone marrow transplantation.

Pooled results of 3 to 5 independent experiments. Number of engrafted mice/number of analyzed mice at day 45 to day 50 post-BMT are indicated in parentheses.

†

P < .001.

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