Main toxicities of induction and consolidation courses
| . | COPAD . | COPADM (MTX = 3) . | CYM . | COPADM (MTX = 8) . | CYVE . |
|---|---|---|---|---|---|
| No. of courses | 103 | 750 | 716 | 261 | 271 |
| Red cell transfusion | 13% | 58% | 31% | 71% | 84% |
| Platelet transfusion | 3% | 17% | 15% | 53% | 82% |
| Mucositis grade 3 | 5% | 23% | 1% | 33% | 6% |
| grade 4 | 0 | 15% | 0 | 21% | 0 |
| Febrile neutropenia | 44% | 82% | 25% | 85% | 73% |
| Severe infection5-150 | 3% | 12% | 5% | 20% | 21% |
| Life-threatening | 0 | 2% | 0.8% | 5% | 0.7 |
| Toxicity-related deaths | 0 | 2 | 1 | 2 | 1 |
| . | COPAD . | COPADM (MTX = 3) . | CYM . | COPADM (MTX = 8) . | CYVE . |
|---|---|---|---|---|---|
| No. of courses | 103 | 750 | 716 | 261 | 271 |
| Red cell transfusion | 13% | 58% | 31% | 71% | 84% |
| Platelet transfusion | 3% | 17% | 15% | 53% | 82% |
| Mucositis grade 3 | 5% | 23% | 1% | 33% | 6% |
| grade 4 | 0 | 15% | 0 | 21% | 0 |
| Febrile neutropenia | 44% | 82% | 25% | 85% | 73% |
| Severe infection5-150 | 3% | 12% | 5% | 20% | 21% |
| Life-threatening | 0 | 2% | 0.8% | 5% | 0.7 |
| Toxicity-related deaths | 0 | 2 | 1 | 2 | 1 |
For abbreviations, see Table 1.
Severe infections include sepsis, urine infection, extensive skin infection, pneumonitis, and “shock” without bacteriologic documentation.