Table 6. Comparison of day 8 bone marrow... | American Society of Hematology

Table 6.

Comparison of day 8 bone marrow and plasma R115777 levels

R115777 dose (mg bid)	Marrow level (ng/g cell pellet)^6-150	Plasma C_min (ng/mL plasma)^6-150	Marrow/plasma ratio^6-150
100-300 (5)^6-151	153 (129-202)	53 (25-109)	2.9 (1.4-6.2)
600 (7)	1742 (812-3920)	655 (322-1544)	2.7 (2.0-3.7)
900 (3)	2942 (2032-3642)	799 (171-1841)	3.7 (1.7, 11.2, 11.9)

R115777 dose (mg bid)	Marrow level (ng/g cell pellet)^6-150	Plasma C_min (ng/mL plasma)^6-150	Marrow/plasma ratio^6-150
100-300 (5)^6-151	153 (129-202)	53 (25-109)	2.9 (1.4-6.2)
600 (7)	1742 (812-3920)	655 (322-1544)	2.7 (2.0-3.7)
900 (3)	2942 (2032-3642)	799 (171-1841)	3.7 (1.7, 11.2, 11.9)

Mean (range).

Number of patients with both marrow and plasma levels determined.