Inhibition of lamin A and HDJ-2 processing in leukemia marrow blasts
| R115777 dose (mg bid) . | No. positive for . | |
|---|---|---|
| Pre–HDJ-2 . | Prelamin A4-150 . | |
| 100 | 0/4 | 0/2 |
| 300 | 0/5 | 0/1 |
| 600 | 5/6 | 4/4 |
| 900 | 6/7 | 0/1 |
| R115777 dose (mg bid) . | No. positive for . | |
|---|---|---|
| Pre–HDJ-2 . | Prelamin A4-150 . | |
| 100 | 0/4 | 0/2 |
| 300 | 0/5 | 0/1 |
| 600 | 5/6 | 4/4 |
| 900 | 6/7 | 0/1 |
Number positive for pre–HDJ-2 or prelamin A/number of assays interpretable. Reasons for uninterpretable prelamin A assays included lack of expression of lamin A (eg, Figure 2B, lanes 14-17) or a decrease in lamin A content during treatment (eg, Figure 2B, lanes 18-21).