Influence of sorted bone marrow T cells on residual host-type blood cells in BALB/c recipients 20 d after bone marrow transplantation
| Bone marrow cells . | Bone marrow T cells . | % Host-type cells . | Fraction of hosts with complete chimerism (< 1% host-type cells) . |
|---|---|---|---|
| Whole BM (25 × 106) | None | < 1 × 10 | 10/10 |
| Whole BM (50 × 106) | None | < 1 × 5 5/5 | |
| TCD BM (25 × 106) | None | 99, 98, 94, 33, 24, 12, 11, 7, 5 | 0/9 |
| TCD BM (50 × 106) | None | 10, 9, 4, 3, 3, 2, 1 | 0/7 |
| TCD BM (25 × 106) | CD8+ (0.1 × 106) | < 1 × 10 | 10/10 |
| TCD BM (50 × 106) | CD8+ (0.1 × 106) | < 1 × 9 | 9/9 |
| TCD BM (50 × 106) | CD8+ (0.3 × 106) | < 1 × 9 | 9/9 |
| TCD BM (50 × 106) | CD4+ (0.1 × 106) | 33, 31, 30, 6, 2 | 0/5 |
| TCD BM (50 × 106) | CD4+ (0.3 × 106) | 82, 64, 50, 15, 14 | 0/5 |
| Bone marrow cells . | Bone marrow T cells . | % Host-type cells . | Fraction of hosts with complete chimerism (< 1% host-type cells) . |
|---|---|---|---|
| Whole BM (25 × 106) | None | < 1 × 10 | 10/10 |
| Whole BM (50 × 106) | None | < 1 × 5 5/5 | |
| TCD BM (25 × 106) | None | 99, 98, 94, 33, 24, 12, 11, 7, 5 | 0/9 |
| TCD BM (50 × 106) | None | 10, 9, 4, 3, 3, 2, 1 | 0/7 |
| TCD BM (25 × 106) | CD8+ (0.1 × 106) | < 1 × 10 | 10/10 |
| TCD BM (50 × 106) | CD8+ (0.1 × 106) | < 1 × 9 | 9/9 |
| TCD BM (50 × 106) | CD8+ (0.3 × 106) | < 1 × 9 | 9/9 |
| TCD BM (50 × 106) | CD4+ (0.1 × 106) | 33, 31, 30, 6, 2 | 0/5 |
| TCD BM (50 × 106) | CD4+ (0.3 × 106) | 82, 64, 50, 15, 14 | 0/5 |
TCD indicates T-cell depleted; BM, bone marrow.