Chimerism 20 d after bone marrow transplantation in peripheral blood of BALB/c hosts given BCL1 tumor
| Cell no. . | C57BL/6 bone marrow donor . | % Host-type cells . | Fraction of hosts with complete chimerism (< 1% host-type cells) . |
|---|---|---|---|
| 6.0 × 106 | Wild-type* | > 99 × 5 | 0/5 |
| 12.5 × 106 | Wild-type | < 1 × 9 | 9/9 |
| 25 × 106 | Wild-type | < 1 × 10 | 10/10 |
| 50 × 106 | Wild-type | < 1 × 5 | 5/5 |
| 50 × 106 | CD4−/− | < 1 × 5 | 5/5 |
| 50 × 106 | CD8−/− | 98, 89, 11, 2, 2, < 1 × 3 | 3/6 |
| 50 × 106 | TCRα−/− | 10, 6, 6, 6, 5, 5, 4, 4, 4, 4 | 0/10 |
| 25 × 106 | Perforin−/− | 98, 94, 4, < 1 × 4 | 4/7 |
| 50 × 106 | Perforin−/− | 6, 4, 4, 2, < 1 × 5 | 5/9 |
| 25 × 106 | FasL−/− | 91, 91, 2, < 1 × 3 | 3/6 |
| 50 × 106 | FasL−/− | 3, 1 × 7 | 7/8 |
| Cell no. . | C57BL/6 bone marrow donor . | % Host-type cells . | Fraction of hosts with complete chimerism (< 1% host-type cells) . |
|---|---|---|---|
| 6.0 × 106 | Wild-type* | > 99 × 5 | 0/5 |
| 12.5 × 106 | Wild-type | < 1 × 9 | 9/9 |
| 25 × 106 | Wild-type | < 1 × 10 | 10/10 |
| 50 × 106 | Wild-type | < 1 × 5 | 5/5 |
| 50 × 106 | CD4−/− | < 1 × 5 | 5/5 |
| 50 × 106 | CD8−/− | 98, 89, 11, 2, 2, < 1 × 3 | 3/6 |
| 50 × 106 | TCRα−/− | 10, 6, 6, 6, 5, 5, 4, 4, 4, 4 | 0/10 |
| 25 × 106 | Perforin−/− | 98, 94, 4, < 1 × 4 | 4/7 |
| 50 × 106 | Perforin−/− | 6, 4, 4, 2, < 1 × 5 | 5/9 |
| 25 × 106 | FasL−/− | 91, 91, 2, < 1 × 3 | 3/6 |
| 50 × 106 | FasL−/− | 3, 1 × 7 | 7/8 |
Recipients without BCL1, tumor cells.