Comparison of the characteristics and treatment outcomes of genotyped versus nongenotyped elderly patients with acute myeloid leukemia
| . | Genotyped (N = 140) . | Not included (N = 94) . | P* . | ||
|---|---|---|---|---|---|
| No. . | % . | No. . | % . | ||
| FAB (%) (central review) | |||||
| M1 | 32 | 23 | 26 | 28 | .0003 |
| M2 | 49 | 35 | 21 | 22 | |
| M3 | 1 | 1 | 0 | 0 | |
| M4 | 19 | 14 | 2 | 2 | |
| M5 | 14 | 10 | 5 | 5 | |
| M6 | 3 | 2 | 5 | 5 | |
| M7 | 0 | 0 | 1 | 1 | |
| Other/unknown | 22 | 16 | 34 | 36 | |
| Cytogenetics | |||||
| Favorable | 9 | 8 | 3 | 4 | .0059 |
| Intermediate | 73 | 67 | 36 | 49 | |
| Unfavorable | 27 | 25 | 35 | 47 | |
| Med | Range | Med | Range | ||
| Age (y) | 67 | 56-88 | 68 | 56-81 | .33 |
| Marrow blasts (%) | 70 | 0-99 | 58 | 0-95 | .0031 |
| WBCs (1000/μL) | 29.0 | 0.7-298 | 2.6 | 0.6-260 | < .0001 |
| Peripheral blasts (%) | 35 | 0-99 | 11 | 0-95 | .0001 |
| CD34+ blasts (%) | 46 | 0-95 | 75 | 0-97 | .0005 |
| Est | 95% CI | Est | 95% CI | ||
| CR (%) | 45 | 37-53 | 48 | 38-58 | .69 |
| OS (median, mo) | 7 | 5-9 | 9 | 6-12 | .48 |
| RFS (median, mo) | 8 | 6-10 | 8 | 6-10 | .27 |
| . | Genotyped (N = 140) . | Not included (N = 94) . | P* . | ||
|---|---|---|---|---|---|
| No. . | % . | No. . | % . | ||
| FAB (%) (central review) | |||||
| M1 | 32 | 23 | 26 | 28 | .0003 |
| M2 | 49 | 35 | 21 | 22 | |
| M3 | 1 | 1 | 0 | 0 | |
| M4 | 19 | 14 | 2 | 2 | |
| M5 | 14 | 10 | 5 | 5 | |
| M6 | 3 | 2 | 5 | 5 | |
| M7 | 0 | 0 | 1 | 1 | |
| Other/unknown | 22 | 16 | 34 | 36 | |
| Cytogenetics | |||||
| Favorable | 9 | 8 | 3 | 4 | .0059 |
| Intermediate | 73 | 67 | 36 | 49 | |
| Unfavorable | 27 | 25 | 35 | 47 | |
| Med | Range | Med | Range | ||
| Age (y) | 67 | 56-88 | 68 | 56-81 | .33 |
| Marrow blasts (%) | 70 | 0-99 | 58 | 0-95 | .0031 |
| WBCs (1000/μL) | 29.0 | 0.7-298 | 2.6 | 0.6-260 | < .0001 |
| Peripheral blasts (%) | 35 | 0-99 | 11 | 0-95 | .0001 |
| CD34+ blasts (%) | 46 | 0-95 | 75 | 0-97 | .0005 |
| Est | 95% CI | Est | 95% CI | ||
| CR (%) | 45 | 37-53 | 48 | 38-58 | .69 |
| OS (median, mo) | 7 | 5-9 | 9 | 6-12 | .48 |
| RFS (median, mo) | 8 | 6-10 | 8 | 6-10 | .27 |
FAB indicates French-American-British; med, median; WBC, white blood cell; est, estimate; CR, complete response; OS, overall survival; RFS, relapse-free survival.
Two-tailed P values based on Fisher exact test for CR; on Pearson χ2 test for FAB and cytogenetic pattern; on Wilcoxon rank sum test for continuous variables; and on log-rank test for overall and RFS.