Table 2. Clinical and laboratory... | American Society of Hematology

Table 2.

Clinical and laboratory features of 12 healthy relatives with Fas defects

Family^*	Race	Gender	Age (y)	LN size (1 to 4+)^†	Splenomegaly/ splenectomy	α/β DNTCs (%) (no./μL³)^‡	Serum IgG (mg/dL)^2-153	Serum IL-10 (pg/ml)	Autoantibodies	Autoimmunity
1	W	F	48	1+	N/N	11 (0.8)	NT	26	NT	ND^f
1	W	F	28	1+	N/N	18 (0.7)	782	6	−	ND
2	W	M	70	1+	N/N	7 (0.5)	688	8	−	ND
2	W	F	41	1+	N/N	8 (0.6)	1010	4	+	ND
4	W	F	34	1+	N/N	36 (1.2)	NT	25	NT	ND
4	W	F	62	1+	N/N	7 (0.3)	1300	5	−	ND
4	W	F	37	1+	N/N	6 (0.3)	844	0	+	ND
5	W	F	37	1+	N/N	9 (0.7)	909	6	+	ND
20	W	M	45	1+	N/N	16 (1.2)	1380	22	−	ND
20	W	F	10	1+	N/N	32 (2.0)	1350	35	−	ND
30	W	F	38	1+	N/N	27 (2.1)	1400	11	+	ND
31	W	M	33	1+	N/N	22 (2.1)	1450	23	−	ND

Family^*	Race	Gender	Age (y)	LN size (1 to 4+)^†	Splenomegaly/ splenectomy	α/β DNTCs (%) (no./μL³)^‡	Serum IgG (mg/dL)^2-153	Serum IL-10 (pg/ml)	Autoantibodies	Autoimmunity
1	W	F	48	1+	N/N	11 (0.8)	NT	26	NT	ND^f
1	W	F	28	1+	N/N	18 (0.7)	782	6	−	ND
2	W	M	70	1+	N/N	7 (0.5)	688	8	−	ND
2	W	F	41	1+	N/N	8 (0.6)	1010	4	+	ND
4	W	F	34	1+	N/N	36 (1.2)	NT	25	NT	ND
4	W	F	62	1+	N/N	7 (0.3)	1300	5	−	ND
4	W	F	37	1+	N/N	6 (0.3)	844	0	+	ND
5	W	F	37	1+	N/N	9 (0.7)	909	6	+	ND
20	W	M	45	1+	N/N	16 (1.2)	1380	22	−	ND
20	W	F	10	1+	N/N	32 (2.0)	1350	35	−	ND
30	W	F	38	1+	N/N	27 (2.1)	1400	11	+	ND
31	W	M	33	1+	N/N	22 (2.1)	1450	23	−	ND

For abbreviations, see Table 1.

The number refers to the family in the NIH ALPS research cohort from whom samples were available for this study.

Lymph node sizes as defined in reference 2.

Normal range of 0 to 18 cells/μL3, or less than 1% of all lymphocytes.

Normal range of 523 to 1482 μg/dL.