Table 3. Biologic modifications during... | American Society of Hematology

Table 3.

Biologic modifications during hydroxyurea therapy

	At start HU (n = 93)	After 1 y (n = 83)	After 2 y (n = 61)	After 3 y (n = 44)	After 4 y (n = 33)	After 5 y (n = 22)
Hb (g/dL) (mean ± SE)	8.2 ± 1.1	8.8 ± 1.2^3-152	9 ± 1.5^3-152	8.7 ± 1.2^3-152	8.2 ± 1.4^3-150	8.7 ± 1.3^3-151
% HbF (mean ± SE)	7.3 ± 6.8	16.7 ± 10.6^3-152	16.1 ± 9.7^3-152	15.6 ± 8.7^3-152	15.3 ± 8^3-152	12.9 ± 6.7^3-152
MCV (fL) (mean ± SE)	83 ± 8.9	93.5 ± 11^3-152	93.4 ± 11^3-152	94.6 ± 12^3-152	95.8 ± 12^3-152	96.9 ± 15^3-152
ANC (10⁹/L) (mean ± SE)	6.0 ± 2.6	3.9 ± 18^3-152	4.5 ± 2.5^3-151	4.2 ± 2.5^3-151	4.2 ± 2^3-152	4.0 ± 2.3^3-152

	At start HU (n = 93)	After 1 y (n = 83)	After 2 y (n = 61)	After 3 y (n = 44)	After 4 y (n = 33)	After 5 y (n = 22)
Hb (g/dL) (mean ± SE)	8.2 ± 1.1	8.8 ± 1.2^3-152	9 ± 1.5^3-152	8.7 ± 1.2^3-152	8.2 ± 1.4^3-150	8.7 ± 1.3^3-151
% HbF (mean ± SE)	7.3 ± 6.8	16.7 ± 10.6^3-152	16.1 ± 9.7^3-152	15.6 ± 8.7^3-152	15.3 ± 8^3-152	12.9 ± 6.7^3-152
MCV (fL) (mean ± SE)	83 ± 8.9	93.5 ± 11^3-152	93.4 ± 11^3-152	94.6 ± 12^3-152	95.8 ± 12^3-152	96.9 ± 15^3-152
ANC (10⁹/L) (mean ± SE)	6.0 ± 2.6	3.9 ± 18^3-152	4.5 ± 2.5^3-151	4.2 ± 2.5^3-151	4.2 ± 2^3-152	4.0 ± 2.3^3-152

HU indicates hydroxyurea; HbF, fetal hemoglobin; MCV, mean corpuscular volume; fL, femtoliter; ANC, absolute neutrophil count.

P value not significant, when compared to baseline.

P < .05, when compared to baseline.

P < .01, when compared to baseline.