Table 2.

Sickle cell disease–related clinical events reported in the Belgian Registry in patients on hydroxyurea

Type of eventAdverse events (no.)Rate/100 patient-years
No. of hospitalizations* 271 106  
ACS 3.5 
Parvovirus infection with aplastic crisis 1.2  
Papillary necrosis 0.8  
Surgery for gallstones 0.8  
Splenic sequestration 0.4  
TIA or stroke 
Osteonecrosis 0  
Priapism 
Type of eventAdverse events (no.)Rate/100 patient-years
No. of hospitalizations* 271 106  
ACS 3.5 
Parvovirus infection with aplastic crisis 1.2  
Papillary necrosis 0.8  
Surgery for gallstones 0.8  
Splenic sequestration 0.4  
TIA or stroke 
Osteonecrosis 0  
Priapism 
*

Mainly for vaso-occlusive crises, but hospitalizations for surgery or infection are also included.

ACS indicates acute chest syndrome; TIA, transient ischemic attack.

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