Table 2.

Activities of FXI/PKA4 chimeras in plasma coagulation assays

Zymogen*Activated enzyme†
PhospholipidPlateletsPhospholipidPlatelets
FXI/PKA4 0.80  ±  0.05 < 0.05 0.59  ±  0.04 < 0.05  
FXI/PKA4-Gly326 0.81  ±  0.04 0.83  ±  0.01 0.77  ±  0.01 0.72  ±  0.04 
Zymogen*Activated enzyme†
PhospholipidPlateletsPhospholipidPlatelets
FXI/PKA4 0.80  ±  0.05 < 0.05 0.59  ±  0.04 < 0.05  
FXI/PKA4-Gly326 0.81  ±  0.04 0.83  ±  0.01 0.77  ±  0.01 0.72  ±  0.04 

Recombinant proteins were tested as described in “Materials and methods.” Results represent the means for 3 separate experiments.

*

Activities determined by kaolin-initiated aPTT assay.

†

Activities determined by modified clotting assay in the absence of kaolin.

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