Table 2. Mutations in the immunoglobulin... | American Society of Hematology

Table 2.

Mutations in the immunoglobulin promoter and complete coding region of Reed-Sternberg cells isolated from 9 cases of classical Hodgkin disease

Case	Number of somatic mutations					Coding capacity	Family
	Promoter		Leader	VH-region
	Octamer motif	TATA box	Leader and intron	FW^*	CDR^†
1	0	0	1	15	9	−	VH-1
2	0	0	1	26	8	+	VH-2
3	0	0	17	41	21	−	VH-3
4	0	0	5	21	22	+ (−)^‡	VH-3
5	0	0	24	34	13	+	VH-3
6	0	0	0	5	7	+	VH-3
7	2	0	13	38	18	+	VH-3
8	0	0	2	10	8	−	VH-3
9	0	0	9	36	17	+	VH-4

Case	Number of somatic mutations					Coding capacity	Family
	Promoter		Leader	VH-region
	Octamer motif	TATA box	Leader and intron	FW^*	CDR^†
1	0	0	1	15	9	−	VH-1
2	0	0	1	26	8	+	VH-2
3	0	0	17	41	21	−	VH-3
4	0	0	5	21	22	+ (−)^‡	VH-3
5	0	0	24	34	13	+	VH-3
6	0	0	0	5	7	+	VH-3
7	2	0	13	38	18	+	VH-3
8	0	0	2	10	8	−	VH-3
9	0	0	9	36	17	+	VH-4

Number of mutations in all framework regions.

Number of mutations in CDR1 and CDR2.

Two HRS cells with an insertion of 22 base pairs resulting in a stop codon.