Table 2. Effects of human globin... | American Society of Hematology

Table 2.

Effects of human globin transgene expression on β-thalassemic erythropoiesis

Mice	Human globin/murine α^†	Hb, g/dL	MCH, pg	RDW	Retic, %	Spleen, mg
THAL	NA	9.13 ± 0.13	12.9 ± 0.27	33.3 ± 0.66	21.8 ± 1.5	392 ± 35
Strain A	0.03	9.77 ± 0.11^*	13.9 ± 0.47	31.0 ± 0.67^*	20.6 ± 1.3	406 ± 52
Strain B	0.07	11.2 ± 0.12^*	14.1 ± 0.31^*	29.6 ± 0.54^*	14.0 ± 1.3^*	208 ± 33^*
Strain C	0.13	12.4 ± 0.60^*	14.9 ± 0.44^*	24.5 ± 0.72^*	7.70 ± 1.4^*	125 ± 13^*
Strain D	0.38	13.9 ± 0.31^*	15.1 ± 0.26^*	19.2 ± 0.69^*	1.95 ± 0.22^*	113 ± 6^*
WT	NA	14.5 ± 0.13^*	16.7 ± 0.17^*	18.5 ± 0.20^*	1.75 ± 0.25^*	99 ± 8^*

Mice	Human globin/murine α^†	Hb, g/dL	MCH, pg	RDW	Retic, %	Spleen, mg
THAL	NA	9.13 ± 0.13	12.9 ± 0.27	33.3 ± 0.66	21.8 ± 1.5	392 ± 35
Strain A	0.03	9.77 ± 0.11^*	13.9 ± 0.47	31.0 ± 0.67^*	20.6 ± 1.3	406 ± 52
Strain B	0.07	11.2 ± 0.12^*	14.1 ± 0.31^*	29.6 ± 0.54^*	14.0 ± 1.3^*	208 ± 33^*
Strain C	0.13	12.4 ± 0.60^*	14.9 ± 0.44^*	24.5 ± 0.72^*	7.70 ± 1.4^*	125 ± 13^*
Strain D	0.38	13.9 ± 0.31^*	15.1 ± 0.26^*	19.2 ± 0.69^*	1.95 ± 0.22^*	113 ± 6^*
WT	NA	14.5 ± 0.13^*	16.7 ± 0.17^*	18.5 ± 0.20^*	1.75 ± 0.25^*	99 ± 8^*

Values represent the mean and SEM.

THAL indicates thalassemic; WT, wild type; Hb, hemoglobin; MCH, mean corpuscular hemoglobin; RDW, red cell distribution width; retic, reticulocyte; Spleen, splenic weight; NA, not applicable.

Statistically significant difference from THAL with P of at least < .006.

†

Ratio of human γ-globin (strains A, B, and C) or human β-globin (strain D) messenger RNA to total mouse α-globin messenger RNA.

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