Table 1. Effects of genetically normal... | American Society of Hematology

Table 1.

Effects of genetically normal HSC chimerism on erythropoiesis in β-thalassemic mice

Group	Normal HSC engraftment, %	Hb, g/dL	MCV, fL	MCH, pg	RDW	Retic, %	Spleen, mg
1	0	9.24 ± 0.27	40.7 ± 0.5	11.6 ± 0.1	29.6 ± 0.6	21.2 ± 1.7	242 ± 8
2	10.0 ± 1.4	10.3 ± 0.1^*	42.9 ± 0.1^†	12.8 ± 0.3^*	27.2 ± 0.7^†	17.8 ± 0.5	132 ± 8^*
3	19.9 ± 0.9	10.9 ± 0.1^*	43.8 ± 0.4^†	13.5 ± 0.2^*	25.1 ± 0.8^†	10.0 ± 1.3^*	118 ± 9^*
4	30.2 ± 0.8	11.2 ± 0.1^*	42.9 ± 0.4^†	13.6 ± 0.2^*	22.3 ± 0.3^†	5.2 ± 1.2^*	102 ± 4^*
5	46.2 ± 2.4	11.7 ± 0.3^*	43.2 ± 0.9^†	13.5 ± 0.4^*	22.3 ± 1.2^†	4.0 ± 0.7^*	101 ± 5^*
6	100	12.1 ± 0.1^*	43.2 ± 0.2^†	13.6 ± 0.4^*	18.8 ± 0.3^†	1.8 ± 0.2^*	95 ± 8^*
NA	Non-Tx HW80	13.5 ± 0.1^*	43.5 ± 0.1^†	13.7 ± 0.1^*	18.0 ± 0.1^†	—	—

Group	Normal HSC engraftment, %	Hb, g/dL	MCV, fL	MCH, pg	RDW	Retic, %	Spleen, mg
1	0	9.24 ± 0.27	40.7 ± 0.5	11.6 ± 0.1	29.6 ± 0.6	21.2 ± 1.7	242 ± 8
2	10.0 ± 1.4	10.3 ± 0.1^*	42.9 ± 0.1^†	12.8 ± 0.3^*	27.2 ± 0.7^†	17.8 ± 0.5	132 ± 8^*
3	19.9 ± 0.9	10.9 ± 0.1^*	43.8 ± 0.4^†	13.5 ± 0.2^*	25.1 ± 0.8^†	10.0 ± 1.3^*	118 ± 9^*
4	30.2 ± 0.8	11.2 ± 0.1^*	42.9 ± 0.4^†	13.6 ± 0.2^*	22.3 ± 0.3^†	5.2 ± 1.2^*	102 ± 4^*
5	46.2 ± 2.4	11.7 ± 0.3^*	43.2 ± 0.9^†	13.5 ± 0.4^*	22.3 ± 1.2^†	4.0 ± 0.7^*	101 ± 5^*
6	100	12.1 ± 0.1^*	43.2 ± 0.2^†	13.6 ± 0.4^*	18.8 ± 0.3^†	1.8 ± 0.2^*	95 ± 8^*
NA	Non-Tx HW80	13.5 ± 0.1^*	43.5 ± 0.1^†	13.7 ± 0.1^*	18.0 ± 0.1^†	—	—

Values represent the mean and SEM.

Non-TX indicates nontransplanted; Hb, hemoglobin; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; RDW, red cell distribution width; retic, reticulocyte; Spleen, splenic weight. Dashes indicate that the measurement was not done.

Statistically significant difference from group 1; P at least < .003.

†

Statistically significant difference from group 1; P at least < .025.

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