Response to therapy in 152 patients presenting with thrombocytopenia, analyzed 2 years after diagnosis, stratified for platelet counts at presentation
| Response . | Severe thrombocytopenia (n = 124) . | Moderate thrombocytopenia (n = 28) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CR . | PR . | MTR . | NR . | Dead . | Secondary IT* . | Lost to follow-up . | CR . | PR† . | Secondary IT* . | |
| Therapy | ||||||||||
| First-line therapy | ||||||||||
| Prednisone | 31 | 3 | — | 2 | 2 | 1 | 2 | 1 | 5 | — |
| Prednisone + splenectomy | 46 | 4 | — | 1 | 1 | 5 | — | 2 | 1 | 2 |
| Second-line therapy‡ | — | — | 4 | 7 | — | 1 | — | — | — | 1 |
| Other therapy2-153 | 5 | 2 | 4 | 2 | 1 | — | — | 1 | — | 2 |
| No therapy | — | — | — | — | — | — | — | 4 | 9 | — |
| All, no. (%) | 82 (54) | 9 (6) | 8 (5) | 12 (8) | 4 (3) | 7 (5) | 2 (1) | 8 (5) | 15 (10) | 5 (3) |
| Response . | Severe thrombocytopenia (n = 124) . | Moderate thrombocytopenia (n = 28) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CR . | PR . | MTR . | NR . | Dead . | Secondary IT* . | Lost to follow-up . | CR . | PR† . | Secondary IT* . | |
| Therapy | ||||||||||
| First-line therapy | ||||||||||
| Prednisone | 31 | 3 | — | 2 | 2 | 1 | 2 | 1 | 5 | — |
| Prednisone + splenectomy | 46 | 4 | — | 1 | 1 | 5 | — | 2 | 1 | 2 |
| Second-line therapy‡ | — | — | 4 | 7 | — | 1 | — | — | — | 1 |
| Other therapy2-153 | 5 | 2 | 4 | 2 | 1 | — | — | 1 | — | 2 |
| No therapy | — | — | — | — | — | — | — | 4 | 9 | — |
| All, no. (%) | 82 (54) | 9 (6) | 8 (5) | 12 (8) | 4 (3) | 7 (5) | 2 (1) | 8 (5) | 15 (10) | 5 (3) |
CR indicates complete response; PR, partial response; MTR, response to maintenance therapy; NR, no response.
Twelve patients were reclassified as having secondary immune thrombocytopenia because they developed an autoimmune disease or malignancy during the first 2 years after the start of thrombocytopenia.
PR at 2 years in patients with moderate thrombocytopenia denotes stable disease.
After failure of first-line therapy.
Described in “Patients and methods.” Splenectomy ultimately resulted in 3 complete and 2 partial responses.