Recovery of donor health status for 3 key outcomes
| . | Physical status6-150,6-151 . | Average pain6-150,6-152 . | Symptom burden6-153,6-155 . | Lost to follow-up . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Good . | Moderate . | Poor . | Mild . | Moderate . | Severe . | Mild . | Moderate . | Severe . | New . | Cumulative . | |
| Day 1 | |||||||||||
| BMT (no.) | 6 | 8(1) | 18(3) | 15(1) | 10 | 8(3) | 9(1) | 13(1) | 11(2) | 4 | 4 |
| % | 18.8 | 25.0 | 56.3 | 45.5 | 30.3 | 24.2 | 27.3 | 39.4 | 33.3 | ||
| PBSC (no.) | 12 | 4(2) | 7 | 15(1) | 3(2) | 5 | 12(1) | 8(1) | 3(1) | 3 | 3 |
| % | 57.2 | 17.4 | 30.4 | 65.2 | 13.0 | 21.7 | 52.2 | 34.8 | 13.0 | ||
| Day 7 | |||||||||||
| BMT (no.) | 14 | 10 | 6(1) | 19 | 11(1) | 0 | 24 | 4 | 2(1) | 1 | 5 |
| % | 46.7 | 3.3 | 20.0 | 63.3 | 36.7 | 0 | 80.0 | 13.3 | 6.7 | ||
| PBSC (no.) | 21(3) | 1 | 1 | 22(3) | 1 | 0 | 22(3) | 1 | 0 | 3 | 6 |
| % | 91.3 | 4.3 | 4.3 | 95.7 | 4.3 | 0 | 95.7 | 4.3 | 0 | ||
| Day 14 | |||||||||||
| BMT (no.) | 23(1) | 4(1) | 2 | 26(2) | 3 | 0 | 25(2) | 4 | 0 | 2 | 7 |
| % | 79.3 | 13.8 | 6.9 | 89.7 | 10.3 | 0 | 86.2 | 13.8 | 0 | ||
| PBSC (no.) | 21(2) | 0 | 0 | 21(2) | 0 | 0 | 21(2) | 0 | 0 | 2 | 8 |
| % | 100 | 0 | 0 | 100 | 0 | 0 | 100 | 0 | 0 | ||
| Day 21 | |||||||||||
| BMT (no.) | 25(3) | 1 | 0 | 23(3) | 2 | 1 | 25(3) | 1 | 0 | 3 | 10 |
| % | 96.2 | 3.8 | 0 | 88.5 | 7.7 | 3.8 | 96.2 | 3.8 | 0 | ||
| PBSC (no.) | 18(1) | 1 | 0 | 19(1) | 0 | 0 | 16 | 3(1) | 0 | 1 | 9 |
| % | 94.7 | 5.3 | 0 | 100 | 0 | 0 | 84.2 | 15.8 | 0 | ||
| Day 28 | |||||||||||
| BMT (no.) | 22 | 1 | 1 | 22 | 2 | 0 | 23 | 1 | 0 | 106-154 | |
| % | 91.7 | 4.2 | 4.2 | 91.7 | 8.3 | 0 | 95.8 | 4.2 | 0 | ||
| PBSC (no.) | 18 | 0 | 0 | 16 | 1 | 1 | 16 | 1 | 1 | 96-154 | |
| % | 100 | 0 | 0 | 88.9 | 5.6 | 5.6 | 88.9 | 5.6 | 5.6 | ||
| . | Physical status6-150,6-151 . | Average pain6-150,6-152 . | Symptom burden6-153,6-155 . | Lost to follow-up . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Good . | Moderate . | Poor . | Mild . | Moderate . | Severe . | Mild . | Moderate . | Severe . | New . | Cumulative . | |
| Day 1 | |||||||||||
| BMT (no.) | 6 | 8(1) | 18(3) | 15(1) | 10 | 8(3) | 9(1) | 13(1) | 11(2) | 4 | 4 |
| % | 18.8 | 25.0 | 56.3 | 45.5 | 30.3 | 24.2 | 27.3 | 39.4 | 33.3 | ||
| PBSC (no.) | 12 | 4(2) | 7 | 15(1) | 3(2) | 5 | 12(1) | 8(1) | 3(1) | 3 | 3 |
| % | 57.2 | 17.4 | 30.4 | 65.2 | 13.0 | 21.7 | 52.2 | 34.8 | 13.0 | ||
| Day 7 | |||||||||||
| BMT (no.) | 14 | 10 | 6(1) | 19 | 11(1) | 0 | 24 | 4 | 2(1) | 1 | 5 |
| % | 46.7 | 3.3 | 20.0 | 63.3 | 36.7 | 0 | 80.0 | 13.3 | 6.7 | ||
| PBSC (no.) | 21(3) | 1 | 1 | 22(3) | 1 | 0 | 22(3) | 1 | 0 | 3 | 6 |
| % | 91.3 | 4.3 | 4.3 | 95.7 | 4.3 | 0 | 95.7 | 4.3 | 0 | ||
| Day 14 | |||||||||||
| BMT (no.) | 23(1) | 4(1) | 2 | 26(2) | 3 | 0 | 25(2) | 4 | 0 | 2 | 7 |
| % | 79.3 | 13.8 | 6.9 | 89.7 | 10.3 | 0 | 86.2 | 13.8 | 0 | ||
| PBSC (no.) | 21(2) | 0 | 0 | 21(2) | 0 | 0 | 21(2) | 0 | 0 | 2 | 8 |
| % | 100 | 0 | 0 | 100 | 0 | 0 | 100 | 0 | 0 | ||
| Day 21 | |||||||||||
| BMT (no.) | 25(3) | 1 | 0 | 23(3) | 2 | 1 | 25(3) | 1 | 0 | 3 | 10 |
| % | 96.2 | 3.8 | 0 | 88.5 | 7.7 | 3.8 | 96.2 | 3.8 | 0 | ||
| PBSC (no.) | 18(1) | 1 | 0 | 19(1) | 0 | 0 | 16 | 3(1) | 0 | 1 | 9 |
| % | 94.7 | 5.3 | 0 | 100 | 0 | 0 | 84.2 | 15.8 | 0 | ||
| Day 28 | |||||||||||
| BMT (no.) | 22 | 1 | 1 | 22 | 2 | 0 | 23 | 1 | 0 | 106-154 | |
| % | 91.7 | 4.2 | 4.2 | 91.7 | 8.3 | 0 | 95.8 | 4.2 | 0 | ||
| PBSC (no.) | 18 | 0 | 0 | 16 | 1 | 1 | 16 | 1 | 1 | 96-154 | |
| % | 100 | 0 | 0 | 88.9 | 5.6 | 5.6 | 88.9 | 5.6 | 5.6 | ||
Numbers in parentheses indicate donors who were lost to follow-up following that assessment. P values correspond to exact permutation tests of equal distributions across donor groups.
BMT indicates bone marrow transplant; PBSC, peripheral blood stem cell.
The 3 categories for physical status and average pain correspond to 0-4, 5-6, and 7-10 divisions on an 11-point scale.
P = .042 for day 1; P = .002 for day 7; P = .102 for day 14; P = .672 for day 21; P = 1.000 for day 28.
P = .284 for day 1; P = .005 for day 7; P = .186 for day 14; P = .501 for day 21; P = .756 for day 28.
The 2 categories for symptom burden were defined by breakpoints at 1.5 and 2.0 on the mean score, which ranged from 1.0 to 4.0 across 23 symptoms.
P = .111 for day 1; P = .307 for day 7; P = .103 for day 14; P = .195 for day 21; P = .712 for day 28.
P = .79, exact test of equality of proportions of cases lost to follow-up.