Effect of human plasmin, miniplasmin, or the Fab fragment of a monoclonal antibody neutralizing murine α2-antiplasmin (Fab-4H9) on focal cerebral ischemic injury in mice and hamsters
| Species . | Compound . | Strain . | Dose, mg . | Injection before ligation . | Injection after ligation . | Combined . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Saline . | Pli . | P . | Saline . | Pli . | P . | Saline . | Pli . | P . | ||||
| Mouse | Pli | SV129 | 0.07 | 6.5 (0.34-7.8) [5] | 1.8 (0.70-7.8) [5] | .53 | 8.0 (3.0-9.0) [3] | 4.8 (3.4-5.3) [3] | .51 | 6.9 (0.34-9.0) [8] | 4.1 (0.70-7.8) [8] | .19 |
| C57Bl/6 | 0.07 | 15 (13-23) [5] | 10 (5.7-16) [6] | .068 | 15 (8.0-20) [7] | 11 (1.8-14) [6] | .063 | 15 (8.0-23) [12] | 11 (1.8-16) [12] | .0079 | ||
| BALB/c | 0.07 | 24 (20-29) [3] | 17 (17-20) [3] | .05 | 28 (23-34) [7] | 23 (22-26) [6] | .038 | 28 (20-34) [10] | 23 (17-26) [9] | .010 | ||
| 0.2 | 26 (24-27) [6] | 22 (20-24) [6] | .007 | 31 (27-32) [6] | 26 (24-28) [6] | .010 | 27 (24-32) [12] | 24 (20-28) [12] | .0027 | |||
| mPli | BALB/c | 0.1 | 26 (20-27) [6] | 24 (18-25) [6] | .14 | — | — | — | — | — | — | |
| 0.2 | 27 (23-32) [6] | 20 (13-26) [6] | .025 | — | — | — | — | — | — | |||
| Fab-4H9 | BALB/c | 1.0 | 26 (21-27) [6] | 22 (15-24) [6] | .055 | — | — | — | — | — | — | |
| 1.7 | — | — | — | 28 (25-30) [6] | 24 (20-27) [6] | .020 | — | — | — | |||
| Hamster | Pli | Pfd Gold | 1.0 | — | — | — | 20 (9.9-38) [6] | 7.0 (0.44-31) [7] | .032 | — | — | — |
| Species . | Compound . | Strain . | Dose, mg . | Injection before ligation . | Injection after ligation . | Combined . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Saline . | Pli . | P . | Saline . | Pli . | P . | Saline . | Pli . | P . | ||||
| Mouse | Pli | SV129 | 0.07 | 6.5 (0.34-7.8) [5] | 1.8 (0.70-7.8) [5] | .53 | 8.0 (3.0-9.0) [3] | 4.8 (3.4-5.3) [3] | .51 | 6.9 (0.34-9.0) [8] | 4.1 (0.70-7.8) [8] | .19 |
| C57Bl/6 | 0.07 | 15 (13-23) [5] | 10 (5.7-16) [6] | .068 | 15 (8.0-20) [7] | 11 (1.8-14) [6] | .063 | 15 (8.0-23) [12] | 11 (1.8-16) [12] | .0079 | ||
| BALB/c | 0.07 | 24 (20-29) [3] | 17 (17-20) [3] | .05 | 28 (23-34) [7] | 23 (22-26) [6] | .038 | 28 (20-34) [10] | 23 (17-26) [9] | .010 | ||
| 0.2 | 26 (24-27) [6] | 22 (20-24) [6] | .007 | 31 (27-32) [6] | 26 (24-28) [6] | .010 | 27 (24-32) [12] | 24 (20-28) [12] | .0027 | |||
| mPli | BALB/c | 0.1 | 26 (20-27) [6] | 24 (18-25) [6] | .14 | — | — | — | — | — | — | |
| 0.2 | 27 (23-32) [6] | 20 (13-26) [6] | .025 | — | — | — | — | — | — | |||
| Fab-4H9 | BALB/c | 1.0 | 26 (21-27) [6] | 22 (15-24) [6] | .055 | — | — | — | — | — | — | |
| 1.7 | — | — | — | 28 (25-30) [6] | 24 (20-27) [6] | .020 | — | — | — | |||
| Hamster | Pli | Pfd Gold | 1.0 | — | — | — | 20 (9.9-38) [6] | 7.0 (0.44-31) [7] | .032 | — | — | — |
The data represent median (range) of infarct volume, in μL3, at 24 hours, followed by the number of observations in brackets.
For abbreviations, see Table 2.