Effect of human plasmin, miniplasmin, or Fab fragment of a monoclonal antibody neutralizing murine α2-antiplasmin (α2-AP) (Fab-4H9) on plasma α2-AP and fibrinogen levels in mice or hamsters
| Species . | Compound . | Dose, mg . | α2-AP, % . | Fibrinogen, g/L . | ||
|---|---|---|---|---|---|---|
| 15 min . | 24 hr . | 15 min . | 24 hr . | |||
| Mouse | Saline | — | — | 120 ± 2 [51] | 0.75 ± 0.14 [5] | 1.0 ± 0.02 [36] |
| Pli | 0.07 | 44 ± 4 [3] | 110 ± 3 [15] | 0.44 ± 0.14 [6] | 1.6 ± 0.02 [6] | |
| 0.2 | 14 ± 4 [3] | 110 ± 10 [6] | 0.09 ± 0.0 [3] | 1.7 ± 0.11 [6] | ||
| mPli | 0.1 | 33 ± 7 [3] | 97 ± 9 [6] | 0.23 ± 0.02 [3] | 1.2 ± 0.06 [6] | |
| 0.2 | 15 ± 3 [6] | 110 ± 2 [6] | 0.22 ± 0.04 [6] | 1.6 ± 0.11 [6] | ||
| Fab-4H9 | 1 | 38 ± 8 [3] | 96 ± 2 [6] | 0.46 ± 0.01 [2] | 1.3 ± 0.13 [6] | |
| 1.7 | — | 110 ± 2 [6] | — | 1.9 ± 0.14 [6] | ||
| Hamster | Saline | — | 100 ± 4 [3] | 130 ± 7 [6] | 0.33 ± 0.01 [3] | 1.7 ± 0.04 [6] |
| Pli | 1 | < 10 [5] | 140 ± 6 [5] | < 0.08 [5] | 1.7 ± 0.06 [6] | |
| Species . | Compound . | Dose, mg . | α2-AP, % . | Fibrinogen, g/L . | ||
|---|---|---|---|---|---|---|
| 15 min . | 24 hr . | 15 min . | 24 hr . | |||
| Mouse | Saline | — | — | 120 ± 2 [51] | 0.75 ± 0.14 [5] | 1.0 ± 0.02 [36] |
| Pli | 0.07 | 44 ± 4 [3] | 110 ± 3 [15] | 0.44 ± 0.14 [6] | 1.6 ± 0.02 [6] | |
| 0.2 | 14 ± 4 [3] | 110 ± 10 [6] | 0.09 ± 0.0 [3] | 1.7 ± 0.11 [6] | ||
| mPli | 0.1 | 33 ± 7 [3] | 97 ± 9 [6] | 0.23 ± 0.02 [3] | 1.2 ± 0.06 [6] | |
| 0.2 | 15 ± 3 [6] | 110 ± 2 [6] | 0.22 ± 0.04 [6] | 1.6 ± 0.11 [6] | ||
| Fab-4H9 | 1 | 38 ± 8 [3] | 96 ± 2 [6] | 0.46 ± 0.01 [2] | 1.3 ± 0.13 [6] | |
| 1.7 | — | 110 ± 2 [6] | — | 1.9 ± 0.14 [6] | ||
| Hamster | Saline | — | 100 ± 4 [3] | 130 ± 7 [6] | 0.33 ± 0.01 [3] | 1.7 ± 0.04 [6] |
| Pli | 1 | < 10 [5] | 140 ± 6 [5] | < 0.08 [5] | 1.7 ± 0.06 [6] | |
The data represent mean ± SEM of the number of observations, which are given in brackets.
Pli indicates human plasmin; mPli, human miniplasmin.