Hemodynamic parameters after intravenous bolus injection in mice or hamsters
| Species . | Saline group . | Pli group . | ||
|---|---|---|---|---|
| Baseline . | 15 min after injection . | Baseline . | 15 min after injection . | |
| Mouse | ||||
| Parameter | ||||
| pH | 7.2 ± 0.02 | 7.2 ± 0.02 | 7.2 ± 0.02 | 7.2 ± 0.01 |
| pco2 | 53 ± 2.7 | 55 ± 3.8 | 53 ± 2.7 | 53 ± 1.1 |
| po2 | 100 ± 9.2 | 110 ± 9.0 | 100 ± 9.2 | 110 ± 7.1 |
| Hb | 18 ± 0.2 | 18 ± 0.2 | 18 ± 0.2 | 19 ± 0.2 |
| MAP | 90 ± 3.4 | 90 ± 6.9 | 90 ± 3.4 | 90 ± 3.7 |
| Hamster | ||||
| Parameter | ||||
| pH | 7.3 ± 0.03 | 7.3 ± 0.02 | 7.3 ± 0.03 | 7.2 ± 0.05 |
| pco2 | 52 ± 2.8 | 52 ± 5.3 | 51 ± 3.6 | 54 ± 2.6 |
| po2 | 95 ± 8.4 | 98 ± 4.0 | 110 ± 11 | 120 ± 16 |
| Hb | 22 ± 1.5 | 21 ± 2.2 | 22 ± 0.3 | 22 ± 0.7 |
| MAP | 98 ± 6.7 | 98 ± 8.1 | 100 ± 3.7 | 100 ± 5.0 |
| Species . | Saline group . | Pli group . | ||
|---|---|---|---|---|
| Baseline . | 15 min after injection . | Baseline . | 15 min after injection . | |
| Mouse | ||||
| Parameter | ||||
| pH | 7.2 ± 0.02 | 7.2 ± 0.02 | 7.2 ± 0.02 | 7.2 ± 0.01 |
| pco2 | 53 ± 2.7 | 55 ± 3.8 | 53 ± 2.7 | 53 ± 1.1 |
| po2 | 100 ± 9.2 | 110 ± 9.0 | 100 ± 9.2 | 110 ± 7.1 |
| Hb | 18 ± 0.2 | 18 ± 0.2 | 18 ± 0.2 | 19 ± 0.2 |
| MAP | 90 ± 3.4 | 90 ± 6.9 | 90 ± 3.4 | 90 ± 3.7 |
| Hamster | ||||
| Parameter | ||||
| pH | 7.3 ± 0.03 | 7.3 ± 0.02 | 7.3 ± 0.03 | 7.2 ± 0.05 |
| pco2 | 52 ± 2.8 | 52 ± 5.3 | 51 ± 3.6 | 54 ± 2.6 |
| po2 | 95 ± 8.4 | 98 ± 4.0 | 110 ± 11 | 120 ± 16 |
| Hb | 22 ± 1.5 | 21 ± 2.2 | 22 ± 0.3 | 22 ± 0.7 |
| MAP | 98 ± 6.7 | 98 ± 8.1 | 100 ± 3.7 | 100 ± 5.0 |
The data represent mean ± SEM 15 minutes after injection in a group of 5 animals. No significant differences existed between the control group, saline group, or Pli group (0.2 mg in mice, 1 mg in hamsters) between before and after Pli treatment.
Pli indicates human plasmin; Hb, hemoglobin; MAP, mean arterial pressure.