Analysis of the 5′-noncoding regulatory region of theBCL-6 gene in cHD of the T- and B-cell genotype
| Patient . | Genotype . | HRS cells . | Reactive cells . | |||
|---|---|---|---|---|---|---|
| Cells studied . | Mutated/unmutated . | Nucleotide changes . | Cells studied . | Identical/nonidentical . | ||
| 1 | T | 19 | 0/5 | None | NA | NA |
| 2 | T | 30 | 0/7 | None | NA | NA |
| 3 | B | 42 | 3/0 | 99A>C | 25 | 0/3 |
| 122G>C3-150 | ||||||
| 448G>C | ||||||
| 4 | B | 50 | 2/4 | 202A>C | 16 | 0/23-151 |
| 284A>G | ||||||
| 300G>C | ||||||
| 397G>C | ||||||
| 5 | B | 42 | 3/1 | 311A>C | 70 | 0/6 |
| 518delG | ||||||
| 6 | B | 19 | 4/1 | 520delT | 61 | 0/5 |
| Patient . | Genotype . | HRS cells . | Reactive cells . | |||
|---|---|---|---|---|---|---|
| Cells studied . | Mutated/unmutated . | Nucleotide changes . | Cells studied . | Identical/nonidentical . | ||
| 1 | T | 19 | 0/5 | None | NA | NA |
| 2 | T | 30 | 0/7 | None | NA | NA |
| 3 | B | 42 | 3/0 | 99A>C | 25 | 0/3 |
| 122G>C3-150 | ||||||
| 448G>C | ||||||
| 4 | B | 50 | 2/4 | 202A>C | 16 | 0/23-151 |
| 284A>G | ||||||
| 300G>C | ||||||
| 397G>C | ||||||
| 5 | B | 42 | 3/1 | 311A>C | 70 | 0/6 |
| 518delG | ||||||
| 6 | B | 19 | 4/1 | 520delT | 61 | 0/5 |
Reference sequence corresponds to AF191831.5Identical/nonidentical indicates the identity of the BCL-6mutations observed in reactive cells with those in HRS cells. Mutations reported as recurrent in FL and DLBCL5 are in bold, and the polymorphism at position 397 (397G>C)5 is in italics.
Del indicates deletion; NA, not analyzed.
Indicates mutation in a RGWY motif.5
The 2 sequences represent both alleles because only one of the 2 sequences has the polymorphism at position 397 (397G>C).5