Table 2. Somatic BCL-6 and IgH mutations... | American Society of Hematology

Table 2.

Somatic BCL-6 and IgHmutations and expression of BCL-6 protein

	IgH somatic mutations	Ig coding capacity	BCL-6 somatic mutations	BCL-6 protein expression
Patient no.
1	NC	NC	0	S
2	NC	NC	0	+
3	17	+	3	−
4	24	+	3	−
5	14	+	2	S
6	29	−	1	+
Cell line
L540	NC	NC	0	−/+
Holden	NC	NC	0	S
L1236	30^*	+^‡	8/15/8^†	S
KMH2	26	+	1	S
L428	20	+	2/8^†	S
L591	26	−	1/0^†	−/+

	IgH somatic mutations	Ig coding capacity	BCL-6 somatic mutations	BCL-6 protein expression
Patient no.
1	NC	NC	0	S
2	NC	NC	0	+
3	17	+	3	−
4	24	+	3	−
5	14	+	2	S
6	29	−	1	+
Cell line
L540	NC	NC	0	−/+
Holden	NC	NC	0	S
L1236	30^*	+^‡	8/15/8^†	S
KMH2	26	+	1	S
L428	20	+	2/8^†	S
L591	26	−	1/0^†	−/+

The BCL-6 somatic mutations are in the 5′-noncoding region.

NC indicates not calculable due to absence of Igrearrangements in the presence of rearranged TCR genes; S, single cells; −/+, 5% to 10%; +, 90% to 100%; −, negative.

Refers to the functional IgH coding region.

†

Indicates the number of BCL-6 mutations on the different alleles. Note: L1236 harbor 3 alleles ofbc16.22

‡

Single base substitution in the IgH promoter region (Octamer binding site).

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