Table 6. Inhibition of Knops antisera... | American Society of Hematology

Table 6.

Inhibition of Knops antisera using various mutants of soluble CR1 LHR-D⁺

CR1 mutant	McC^a-1	McC^a-2	McC^b	Sl^a-1	Sl^a-2	Sl^a-3	Sl^a-4	Vil
1590K-1601R^6-150	I	I	NI	I	I	I	I	NI
1590E-1601R	NI	NI	I	NI	NI	NI	NI	NI
1590R-1601R	NI	NI	NI	I	I	I	I	NI
1590K-1601G	I	I	NI	NI	NI	NI	NI	I
1590E-1601G	NI	NI	I	NI	NI	NI	NI	I

CR1 mutant	McC^a-1	McC^a-2	McC^b	Sl^a-1	Sl^a-2	Sl^a-3	Sl^a-4	Vil
1590K-1601R^6-150	I	I	NI	I	I	I	I	NI
1590E-1601R	NI	NI	I	NI	NI	NI	NI	NI
1590R-1601R	NI	NI	NI	I	I	I	I	NI
1590K-1601G	I	I	NI	NI	NI	NI	NI	I
1590E-1601G	NI	NI	I	NI	NI	NI	NI	I

I indicates inhibition; NI, no inhibition.

F6-150

Wild-type LHR-D⁺; same as in Table 3. Mutations at 1590 and 1601 are noted in bold type. 1590K = McC^a; 1590E = McC^b (allele to McC^a); 1590R = no change in net charge; 1601R = Sl^a; 1601G = Vil (allele to Sl^a).

View Large

This Feature Is Available To Subscribers Only