Comparison of SGD and C/EBPε−/− phenotypes
| Phenotype . | SGD . | C/EBPε−/− . |
|---|---|---|
| Neutrophils | ||
| Granule proteins* | ||
| Primary | HNP−, BPI− | Present† |
| Secondary | LF−, NC−, TC−, CAP18− | LF−, NC−, NGAL−, CRAMP−, B9− |
| Tertiary | NG− | NG− |
| Nuclear morphology | Bi-lobed | Bi-lobed |
| Migration | Abnormal | Abnormal |
| Bactericidal activity | Impaired | Impaired |
| Eosinophils | ||
| Granule proteins | MBP−, EDN−, ECP−, EPO+ | MBP−, EPO− |
| Bacterial infection | Staphylococcu aureus, Psuedomonas aeruginosa, Klebsiella | Pseudomonas aeruginosa |
| Phenotype . | SGD . | C/EBPε−/− . |
|---|---|---|
| Neutrophils | ||
| Granule proteins* | ||
| Primary | HNP−, BPI− | Present† |
| Secondary | LF−, NC−, TC−, CAP18− | LF−, NC−, NGAL−, CRAMP−, B9− |
| Tertiary | NG− | NG− |
| Nuclear morphology | Bi-lobed | Bi-lobed |
| Migration | Abnormal | Abnormal |
| Bactericidal activity | Impaired | Impaired |
| Eosinophils | ||
| Granule proteins | MBP−, EDN−, ECP−, EPO+ | MBP−, EPO− |
| Bacterial infection | Staphylococcu aureus, Psuedomonas aeruginosa, Klebsiella | Pseudomonas aeruginosa |
SGD indicates neutrophil-specific granule deficiency (SGD); C/EBPε, CCAAT/enhancer binding protein-ε; HNP, human neutrophil peptide; BPI, bactericidal/permeability-increasing; LF, lactoferrin; NC, neutrophil collagenase; TC, transcobalamin; CAP18, 18-kd cationic antimicrobial protein; NGAL, neutrophil gelatinase-associated lipocalin; CRAMP, cathelin-related antimicrobial peptide; NG, neutrophil gelatinase; MBP, major basic protein; EDN, eosinophil-derived neurotoxin; ECP, eosinophil cationic protein; EPO, eosinophil peroxidase. The (−) denotes severely reduced levels or complete absence of messenger RNA or protein. The (+) indicates presence was detected.
The citations for these data are referred to in the text of this manuscript.
Defensins (HNPs) are not normally expressed in the neutrophils of mice. A murine BPI gene has not been described.