Summary of mouse peripheral blood progenitor cell mobilization
| Mobilization method . | Experiments, no. . | Peak CFU-GM/mL blood . | |
|---|---|---|---|
| Mean . | Quartile, 25% to 75% . | ||
| Vehicle alone | 89 | 47 | 24-63 |
| SB-251353 alone | 107 | 525* | 314-602 |
| G-CSF alone | 31 | 1432* | 452-1911 |
| SB-251353 + G-CSF | 14 | 4483*,† | 1808-3377 |
| Mobilization method . | Experiments, no. . | Peak CFU-GM/mL blood . | |
|---|---|---|---|
| Mean . | Quartile, 25% to 75% . | ||
| Vehicle alone | 89 | 47 | 24-63 |
| SB-251353 alone | 107 | 525* | 314-602 |
| G-CSF alone | 31 | 1432* | 452-1911 |
| SB-251353 + G-CSF | 14 | 4483*,† | 1808-3377 |
BDF1 mice were injected with either PBS, a single SQ dose of 2.5 mg/kg SB-251353, 50 μg/kg G-CSF SQ bid for 4 days, or the combination of G-CSF followed by a single SB-251353 treatment 16 hours after the last dose of G-CSF. Peak CFU-GM mobilization for each experiment is presented as a pooled value from a minimum of 3 mice per group per experiment. The 25% to 75% quartile range is presented as an indication of variability.
CFU-GM indicates colony-forming unit granulocyte-macrophage; G-CSF, granulocyte colony-stimulating factor.
P < .001 compared with PBS.
P = .0019 compared with G-CSF alone.