Treatment and response in 11 chemotherapy-naı̈ve patients with myelofibrosis with myeloid metaplasia at the time of discontinuation of their treatment with interferon alpha
| Patient . | Duration of IFNα Rx (mo) . | Change in Hgb (g/dL) . | Change in WBC count (× 109/L) . | Change in platelet count (× 109/L) . | Change in spleen size (cm) . | Constitutional toxicity of IFNα . |
|---|---|---|---|---|---|---|
| 1 | 12 | 12.7 → 11.0 | 5.3 → 4.1 | 395 → 211 | 11 → 11 | Moderate |
| 2 | 12 | 11.5 → 11.2 | 9.2 → 5.9 | 162 → 118 | 10 → 10 | None |
| 3 | 12 | 14.5 → 14.1 | 8.1 → 9.5 | 321 → 322 | 20 → 15 | Moderate |
| 4 | 12 | 10.6 → 9.1 | 4.6 → 2.5 | 188 → 100 | Tip → 2 | None |
| 5 | 6 | 13.9 → 13.1 | 18.2 → 28.2 | 127 → 85 | 20 → 20* | Severe |
| 6 | 6 | 9.3 → 7.8 | 16.7 → 25.5 | 402 → 158 | 21 → 22 | Severe |
| 7 | 5 | 10.1 → 8.5 | 5.9 → 3.3 | 208 → 155 | 13 → 8 | Severe |
| 8 | 4 | 11.7 → 9.9 | 14.0 → 19.7 | 106 → 44 | 4 → 6 | Severe |
| 9 | 3 | 9.9 → Tx | 4.4 → 5.0 | 129 → 23 | 20 → 20 | Moderate |
| 10 | 3 | 11.8 → 9.4 | 77.3 → 88.1 | 152 → 86 | 12 → 18 | None |
| 11 | 0.3 | N/A | N/A | N/A | N/A | Severe |
| Patient . | Duration of IFNα Rx (mo) . | Change in Hgb (g/dL) . | Change in WBC count (× 109/L) . | Change in platelet count (× 109/L) . | Change in spleen size (cm) . | Constitutional toxicity of IFNα . |
|---|---|---|---|---|---|---|
| 1 | 12 | 12.7 → 11.0 | 5.3 → 4.1 | 395 → 211 | 11 → 11 | Moderate |
| 2 | 12 | 11.5 → 11.2 | 9.2 → 5.9 | 162 → 118 | 10 → 10 | None |
| 3 | 12 | 14.5 → 14.1 | 8.1 → 9.5 | 321 → 322 | 20 → 15 | Moderate |
| 4 | 12 | 10.6 → 9.1 | 4.6 → 2.5 | 188 → 100 | Tip → 2 | None |
| 5 | 6 | 13.9 → 13.1 | 18.2 → 28.2 | 127 → 85 | 20 → 20* | Severe |
| 6 | 6 | 9.3 → 7.8 | 16.7 → 25.5 | 402 → 158 | 21 → 22 | Severe |
| 7 | 5 | 10.1 → 8.5 | 5.9 → 3.3 | 208 → 155 | 13 → 8 | Severe |
| 8 | 4 | 11.7 → 9.9 | 14.0 → 19.7 | 106 → 44 | 4 → 6 | Severe |
| 9 | 3 | 9.9 → Tx | 4.4 → 5.0 | 129 → 23 | 20 → 20 | Moderate |
| 10 | 3 | 11.8 → 9.4 | 77.3 → 88.1 | 152 → 86 | 12 → 18 | None |
| 11 | 0.3 | N/A | N/A | N/A | N/A | Severe |
IFNα indicates interferon alpha; Rx, treatment; Hgb, hemoglobin; WBC, white blood cell; Tx, became transfusion dependent; N/A, not applicable because the patient discontinued treatment after 10 days because of severe toxicity.
The spleen did increase in size, extending to the right across the midline.