Cytotoxic activity to YAC-1 cells of spleen cells cultured with recombinant mouse interleukin-2 for 10 days
| E/T ratio . | CMA treatment . | Specific 51Cr release (%)4-150 . | ||
|---|---|---|---|---|
| +/+ . | mi/mi . | tg/tg . | ||
| 10 | No | 15.6 ± 1.1 | 7.8 ± 0.74-151 | 15.0 ± 1.1 |
| 40 | No | 41.6 ± 2.5 | 15.7 ± 2.14-151 | 45.2 ± 3.2 |
| 75 | No | 52.5 ± 2.8 | 18.5 ± 2.24-151 | 55.3 ± 3.9 |
| 75 | Yes | 18.4 ± 1.0‡ | 10.5 ± 1.2 | 18.5 ± 1.8‡ |
| E/T ratio . | CMA treatment . | Specific 51Cr release (%)4-150 . | ||
|---|---|---|---|---|
| +/+ . | mi/mi . | tg/tg . | ||
| 10 | No | 15.6 ± 1.1 | 7.8 ± 0.74-151 | 15.0 ± 1.1 |
| 40 | No | 41.6 ± 2.5 | 15.7 ± 2.14-151 | 45.2 ± 3.2 |
| 75 | No | 52.5 ± 2.8 | 18.5 ± 2.24-151 | 55.3 ± 3.9 |
| 75 | Yes | 18.4 ± 1.0‡ | 10.5 ± 1.2 | 18.5 ± 1.8‡ |
E/T ratio indicates the ratio of cultured spleen cells to YAC-1 cells; CMA, concanamycin A.
Mean ± SE of 3 experiments.
P < .05 by t test when compared with the values of +/+ and tg/tg spleen cells.
P < .05 by t test when compared with the values of +/+ and tg/tg spleen cells in the absence of CMA.