Laboratory evaluation of the proband
| Laboratory test . | Proband data . | Normal range . |
|---|---|---|
| PT, seconds | 18.4 | 11.1-13.1 |
| aPTT, seconds | 48.7 | 25.0-34.0 |
| Fibrinogen, (μmol/L) | 6.1 | 4.9-12.1 |
| (mg/dL) | (208) | (170-410) |
| Factor II, % | 94 | 83-117 |
| Factor V, % | 111 | 50-150 |
| Factor VII, % | 70 | 65-135 |
| Factor VIII, % | 59 | 55-145 |
| Factor IX, % | 74 | 60-140 |
| Factor X, % | 81 | 45-156 |
| Factor XI, % | 76 | 75-135 |
| Factor XII, % | 82 | 50-150 |
| Thrombin time, seconds | 20.1 | 18.0-22.0 |
| Antithrombin III function, % | 90 | 80-180 |
| Antithrombin III antigen, mg/L | 260 | 210-350 |
| (mg/dL) | (26) | (21-35) |
| vWF, ristocetin cofactor | 54 | 45-140 |
| Bleeding time, minutes | 6.0 | 3.0-8.0 |
| Platelet number and aggregation | Normal | — |
| RVVT, seconds | 26.6 | 25-30 |
| Protein C, % | 68 | 55-140 |
| Activated protein C resistance, ratio | 2.8 | 2.2-4.0 |
| Laboratory test . | Proband data . | Normal range . |
|---|---|---|
| PT, seconds | 18.4 | 11.1-13.1 |
| aPTT, seconds | 48.7 | 25.0-34.0 |
| Fibrinogen, (μmol/L) | 6.1 | 4.9-12.1 |
| (mg/dL) | (208) | (170-410) |
| Factor II, % | 94 | 83-117 |
| Factor V, % | 111 | 50-150 |
| Factor VII, % | 70 | 65-135 |
| Factor VIII, % | 59 | 55-145 |
| Factor IX, % | 74 | 60-140 |
| Factor X, % | 81 | 45-156 |
| Factor XI, % | 76 | 75-135 |
| Factor XII, % | 82 | 50-150 |
| Thrombin time, seconds | 20.1 | 18.0-22.0 |
| Antithrombin III function, % | 90 | 80-180 |
| Antithrombin III antigen, mg/L | 260 | 210-350 |
| (mg/dL) | (26) | (21-35) |
| vWF, ristocetin cofactor | 54 | 45-140 |
| Bleeding time, minutes | 6.0 | 3.0-8.0 |
| Platelet number and aggregation | Normal | — |
| RVVT, seconds | 26.6 | 25-30 |
| Protein C, % | 68 | 55-140 |
| Activated protein C resistance, ratio | 2.8 | 2.2-4.0 |
PT indicates prothrombin time; aPTT, activated partial thromboplastin time, AT3, antithrombin III; vWF, von Willebrand factor; RVVT, Russell viper venom time.