Study subject characteristics
| Subject . | Hemogram . | Disease manifestations . | ||||
|---|---|---|---|---|---|---|
| Patient (phenotype) . | Sex . | Age, y . | Hb, g/L . | WBCs, ×109/L . | Platelets, ×109/L . | |
| A (HbSS) | F | 24 | 9 | 12 000 | 340 000 | 3 pain crises per year 3 acute chest syndrome events |
| B (Hbβ+thal) | M | 28 | 8 | 13 500 | 290 000 | <1 pain crisis per year 1 acute chest syndrome event 1 splenic sequestration crisis |
| C (HbSC) | M | 39 | 13 | 13 000 | 375 000 | 1 pain crisis per year splenic infarction retinopathy |
| Subject . | Hemogram . | Disease manifestations . | ||||
|---|---|---|---|---|---|---|
| Patient (phenotype) . | Sex . | Age, y . | Hb, g/L . | WBCs, ×109/L . | Platelets, ×109/L . | |
| A (HbSS) | F | 24 | 9 | 12 000 | 340 000 | 3 pain crises per year 3 acute chest syndrome events |
| B (Hbβ+thal) | M | 28 | 8 | 13 500 | 290 000 | <1 pain crisis per year 1 acute chest syndrome event 1 splenic sequestration crisis |
| C (HbSC) | M | 39 | 13 | 13 000 | 375 000 | 1 pain crisis per year splenic infarction retinopathy |
The indicated hemogram is typical for each subject in their steady state. All subjects were taking folate as their only medication.