Sensitivity, specificity, predictive values, and efficacy according to different estimates
| Analysis based on premortem stratification . | HDG . | Final analysis after incorporating autopsy findings . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Estimate, % . | A . | B . | C . | D . | A . | B . | C . | D . | |
| Sensitivity | 100 | 72.9 | 31.3 | 72.9 | 91 | 100 | 89.7 | 41.9 | 89.7 |
| Specificity | 99.1 | 99.1 | 99.1 | 94.7 | 91.5 | 98.1 | 98.1 | 98.1 | 97.1 |
| PPV | 77.7 | 93.1 | 95.4 | 61.3 | 88.2 | 85.7 | 87.5 | 88.6 | 79.5 |
| NPV | 100 | 95.7 | 70.8 | 96.8 | 93.5 | 100 | 98.4 | 82.7 | 98.7 |
| Efficacy | 99.1 | 95.4 | 73.9 | 92.5 | 91.2 | 98.3 | 97.0 | 83.5 | 96.3 |
| Analysis based on premortem stratification . | HDG . | Final analysis after incorporating autopsy findings . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Estimate, % . | A . | B . | C . | D . | A . | B . | C . | D . | |
| Sensitivity | 100 | 72.9 | 31.3 | 72.9 | 91 | 100 | 89.7 | 41.9 | 89.7 |
| Specificity | 99.1 | 99.1 | 99.1 | 94.7 | 91.5 | 98.1 | 98.1 | 98.1 | 97.1 |
| PPV | 77.7 | 93.1 | 95.4 | 61.3 | 88.2 | 85.7 | 87.5 | 88.6 | 79.5 |
| NPV | 100 | 95.7 | 70.8 | 96.8 | 93.5 | 100 | 98.4 | 82.7 | 98.7 |
| Efficacy | 99.1 | 95.4 | 73.9 | 92.5 | 91.2 | 98.3 | 97.0 | 83.5 | 96.3 |
HDG indicates analysis of histologically documented group; PPV, positive predictive value; and NPV, negative predictive value.