Patient and treatment characteristics (n = 110, except where indicated)
Parameter at diagnosis . | No. of patients . | % . |
---|---|---|
Age ≥ 60 y | 33 | 30 |
Stage III | 64 | 58 |
PCL | 6 | 5 |
B substage (n = 104) | 11 | 11 |
IgA isotype (n = 108) | 23 | 21 |
λ light chain (n = 108) | 36 | 33 |
β2m ≥ 2.5 mg/L | 79 | 71 |
CRP ≥ 6 mg/L (n = 102) | 43 | 42 |
Bone marrow plasmacytosis > 25% (n = 108) | 74 | 69 |
Albumin ≤ 35 g/L (n = 108) | 30 | 28 |
Type of HDT | ||
HDM 140 alone | 5 | 5 |
1 autotransplant | 62 | 56 |
Tandem autotransplants | 20 | 18 |
1 HDT at diagnosis + 1 autotransplant at first relapse | 21 | 19 |
Other type* | 2 | 2 |
Parameter at diagnosis . | No. of patients . | % . |
---|---|---|
Age ≥ 60 y | 33 | 30 |
Stage III | 64 | 58 |
PCL | 6 | 5 |
B substage (n = 104) | 11 | 11 |
IgA isotype (n = 108) | 23 | 21 |
λ light chain (n = 108) | 36 | 33 |
β2m ≥ 2.5 mg/L | 79 | 71 |
CRP ≥ 6 mg/L (n = 102) | 43 | 42 |
Bone marrow plasmacytosis > 25% (n = 108) | 74 | 69 |
Albumin ≤ 35 g/L (n = 108) | 30 | 28 |
Type of HDT | ||
HDM 140 alone | 5 | 5 |
1 autotransplant | 62 | 56 |
Tandem autotransplants | 20 | 18 |
1 HDT at diagnosis + 1 autotransplant at first relapse | 21 | 19 |
Other type* | 2 | 2 |
PCL indicates primary plasma cell leukemia; HDT, high-dose therapy; HDM 140, high-dose melphalan 140 mg/m2.
One allogeneic bone marrow transplant and one autotransplant followed by an allogeneic transplant.