Table 1. QTc intervals and electrolytes... | American Society of Hematology

Table 1.

QTc intervals and electrolytes in the patients with torsades de pointes

Days of treatment	QT	HR	QTc (msec)	Cumulative dose of arsenic (mg)	K	Mg
Patient 1
Day 36	0.29	120	0.41	720	3.5	—
Day 38	0.24	166	0.40	760	2.9	3.6
Day 41	0.28	150	0.45	820	3.9	2.0
Day 42 (TDP)	0.28	146	0.44	840	3.3	1.7
Patient 2
Pretreatment	0.26	152	0.42	0	4.0	1.8
Day 7	0.32	112	0.42	140	3.8	2.1
Day 12	0.34	105	0.45	240	3.1	—
Day 15	0.28	160	0.46	300	3.1	—
Day 16 (TDP)	0.32	136	0.48	320	3.1	1.5
Patient 3
Pretreatment	0.32	112	0.435	0	2.7	1.2
Day 3	0.32	126	0.43	20	2.8	1.4
Day 8	0.36	110	0.48	70	3.0	1.6
Day 9	0.3	164	0.5	70^*	3.0	1.4
Day 10	0.32	146	0.48	70	3.5	2.1
Day 12 (TDP)	0.3	136	0.45	70	4.0	2.5

Days of treatment	QT	HR	QTc (msec)	Cumulative dose of arsenic (mg)	K	Mg
Patient 1
Day 36	0.29	120	0.41	720	3.5	—
Day 38	0.24	166	0.40	760	2.9	3.6
Day 41	0.28	150	0.45	820	3.9	2.0
Day 42 (TDP)	0.28	146	0.44	840	3.3	1.7
Patient 2
Pretreatment	0.26	152	0.42	0	4.0	1.8
Day 7	0.32	112	0.42	140	3.8	2.1
Day 12	0.34	105	0.45	240	3.1	—
Day 15	0.28	160	0.46	300	3.1	—
Day 16 (TDP)	0.32	136	0.48	320	3.1	1.5
Patient 3
Pretreatment	0.32	112	0.435	0	2.7	1.2
Day 3	0.32	126	0.43	20	2.8	1.4
Day 8	0.36	110	0.48	70	3.0	1.6
Day 9	0.3	164	0.5	70^*	3.0	1.4
Day 10	0.32	146	0.48	70	3.5	2.1
Day 12 (TDP)	0.3	136	0.45	70	4.0	2.5

Arsenic discontinued, not restarted; HR, heart rate.

Normal ranges: K, 3.5 to 5.0 mEq/L; Mg, 1.4 to 2.6 mg/dL.

Normal QTc interval, ≤ 0.44 seconds.