Comparison of PTLD in humans and miniature swine
| . | Humans . | Miniature swine . |
|---|---|---|
| Mean time to onset | Variable, may be < 6 mo | ∼34 d |
| Increased risk with increased immunosuppression | Yes | Likely, but not definitively demonstrated |
| Sites involved | Lymph nodes, GI tract, tonsils and adenoids, allograft, others | Lymph nodes, tonsils |
| Response to decreased immunosuppression | Sometimes | Sometimes |
| Outcome | Fatal in approximately 50% | Fatal in 6 of 9 |
| Incidence | < 9% | > 40% |
| Histology | Polymorphous or monomorphous | Polymorphous |
| Lineage | B cell | B cell |
| Origin | Mainly host (solid organ) mainly donor (BMT) | Host, 8 of 9 |
| Virus present | EBV, most cases | pGHV, high copy number |
| . | Humans . | Miniature swine . |
|---|---|---|
| Mean time to onset | Variable, may be < 6 mo | ∼34 d |
| Increased risk with increased immunosuppression | Yes | Likely, but not definitively demonstrated |
| Sites involved | Lymph nodes, GI tract, tonsils and adenoids, allograft, others | Lymph nodes, tonsils |
| Response to decreased immunosuppression | Sometimes | Sometimes |
| Outcome | Fatal in approximately 50% | Fatal in 6 of 9 |
| Incidence | < 9% | > 40% |
| Histology | Polymorphous or monomorphous | Polymorphous |
| Lineage | B cell | B cell |
| Origin | Mainly host (solid organ) mainly donor (BMT) | Host, 8 of 9 |
| Virus present | EBV, most cases | pGHV, high copy number |
GI indicates gastrointestinal; BMT, bone marrow transplantation.