Table 1. Summary of animals developing... | American Society of Hematology

Table 1.

Summary of animals developing PTLD

Animal no.	CyA treatment (d)	Time to PTLD onset (d)	Clinical outcome	Histology of PTLD lymph node (LN)	pGHV (LN)
12 757	30	34	PTLD completely resolved	ND	ND
13 100	30	35	PTLD resolved/SAC due to GvHD d 73	ND	ND
13 318	30	32	Died due to complications of PTLD d 32	Polymorphous	+++
13 271^*	24	21	Died due to complications of PTLD d 24	Polymorphous	+++
13 432^*	36^†	34	Died due to complications of PTLD d 39	Polymorphous	+++
13 433^*	37	34	Died due to complications of PTLD d 37	Polymorphous	+++
13 629^*	48^†	48	PTLD resolved/SAC due to GvHD d 69	Polymorphous	+++
13 813^*	28	26	Died due to complications of PTLD d 28	Polymorphous	+++
13 801^*	45^†	45	Died due to complications of PTLD d 48	Polymorphous	+++

Animal no.	CyA treatment (d)	Time to PTLD onset (d)	Clinical outcome	Histology of PTLD lymph node (LN)	pGHV (LN)
12 757	30	34	PTLD completely resolved	ND	ND
13 100	30	35	PTLD resolved/SAC due to GvHD d 73	ND	ND
13 318	30	32	Died due to complications of PTLD d 32	Polymorphous	+++
13 271^*	24	21	Died due to complications of PTLD d 24	Polymorphous	+++
13 432^*	36^†	34	Died due to complications of PTLD d 39	Polymorphous	+++
13 433^*	37	34	Died due to complications of PTLD d 37	Polymorphous	+++
13 629^*	48^†	48	PTLD resolved/SAC due to GvHD d 69	Polymorphous	+++
13 813^*	28	26	Died due to complications of PTLD d 28	Polymorphous	+++
13 801^*	45^†	45	Died due to complications of PTLD d 48	Polymorphous	+++

Eight of 21 animals were treated with the 30-day CyA protocol. Two developed transient PTLD and one died of PTLD complications. Thirteen of 21 animals were treated with the 60-day CyA protocol (none of the 6 developing PTLD completed their 60-day CyA course).

+++ indicates greater than 10² copies pGHV/cell; ND, not determined; SAC, sacrificed.

Animals included in 60-day CyA protocol.

†

CyA stopped early in attempt to resolve PTLD.

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