Sequence analysis of the rearranged Igλ gene in KSHV-positive cells
| Case no. . | Lesion . | Total no. of clones . | Clones with identical Vλ . | Clones with identical CDR3 . | Mutation in Vλ . |
|---|---|---|---|---|---|
| 6 (DPL11) | 6 | 1s | |||
| 1 (DPL15) | 1R | ||||
| Lymphoma (LN) | 10 | 1 (DPL8) | 1R | ||
| 1 (DPL18) | — | ||||
| 1 | 5 (DPL3) | 1s | |||
| 3 | 1s | ||||
| 3 (DPL19) | |||||
| Microlymphoma 1 (Sp) | 17 | 3 (DPL11) | 3 identical to the dominant lymphoma clone | 2R | |
| 1 (DPL3) | — | ||||
| 1 (G7) | — | ||||
| 1 (DPL5) | 2R, 1s |
| Case no. . | Lesion . | Total no. of clones . | Clones with identical Vλ . | Clones with identical CDR3 . | Mutation in Vλ . |
|---|---|---|---|---|---|
| 6 (DPL11) | 6 | 1s | |||
| 1 (DPL15) | 1R | ||||
| Lymphoma (LN) | 10 | 1 (DPL8) | 1R | ||
| 1 (DPL18) | — | ||||
| 1 | 5 (DPL3) | 1s | |||
| 3 | 1s | ||||
| 3 (DPL19) | |||||
| Microlymphoma 1 (Sp) | 17 | 3 (DPL11) | 3 identical to the dominant lymphoma clone | 2R | |
| 1 (DPL3) | — | ||||
| 1 (G7) | — | ||||
| 1 (DPL5) | 2R, 1s |
Clones with frequent mutations (> 5) were occasionally seen. They are most likely from reactive B cells rather than KSHV-positive plasmablasts and are not included.
S indicates silent mutation; R, replacement change; —, no mutation; LN, lymph node; Sp, spleen.