Association between TAFI genotypes and plasma TAFI Ag levels
| Polymorphism . | n . | TAFI Ag level geometric mean (95% CI) . | R2 assuming a codominant model . |
|---|---|---|---|
| C-2599G | |||
| CC | 31 | 97.5 (56.3-168.8) | |
| CG | 62 | 68.7 (37.4-126.2) | 0.25 |
| GG | 27 | 58.0 (28.1-119.7) | |
| −2345 2G/1G | |||
| 2G/2G | 57 | 62.8 (33.5-117.6) | |
| 2G/1G | 51 | 77.5 (39.0-153.9) | 0.20 |
| 1G/1G | 12 | 106.7 (68.0-167.5) | |
| G-438A | |||
| GG | 59 | 90.0 (50.0-162.1) | |
| GA | 54 | 60.9 (37.3-99.5) | 0.41 |
| AA | 7 | 42.5 (20.6-87.8) | |
| Ala147Thr | |||
| Ala/Ala | 62 | 60.9 (31.9-116.4) | |
| Ala/Thr | 56 | 84.8 (48.0-149.7) | 0.23 |
| Thr/Thr | 2 | 100.5 (70.6-143.0) | |
| C+1542G | |||
| CC | 57 | 91.8 (55.2-152.9) | |
| CG | 55 | 62.8 (39.2-100.5) | 0.52 |
| GG | 8 | 35.2 (23.8-52.0) | |
| T+1583A | |||
| TT | 62 | 60.9 (31.9-116.4) | |
| TA | 44 | 81.5 (45.2-146.6) | 0.30 |
| AA | 14 | 107.8 (71.4-162.7) |
| Polymorphism . | n . | TAFI Ag level geometric mean (95% CI) . | R2 assuming a codominant model . |
|---|---|---|---|
| C-2599G | |||
| CC | 31 | 97.5 (56.3-168.8) | |
| CG | 62 | 68.7 (37.4-126.2) | 0.25 |
| GG | 27 | 58.0 (28.1-119.7) | |
| −2345 2G/1G | |||
| 2G/2G | 57 | 62.8 (33.5-117.6) | |
| 2G/1G | 51 | 77.5 (39.0-153.9) | 0.20 |
| 1G/1G | 12 | 106.7 (68.0-167.5) | |
| G-438A | |||
| GG | 59 | 90.0 (50.0-162.1) | |
| GA | 54 | 60.9 (37.3-99.5) | 0.41 |
| AA | 7 | 42.5 (20.6-87.8) | |
| Ala147Thr | |||
| Ala/Ala | 62 | 60.9 (31.9-116.4) | |
| Ala/Thr | 56 | 84.8 (48.0-149.7) | 0.23 |
| Thr/Thr | 2 | 100.5 (70.6-143.0) | |
| C+1542G | |||
| CC | 57 | 91.8 (55.2-152.9) | |
| CG | 55 | 62.8 (39.2-100.5) | 0.52 |
| GG | 8 | 35.2 (23.8-52.0) | |
| T+1583A | |||
| TT | 62 | 60.9 (31.9-116.4) | |
| TA | 44 | 81.5 (45.2-146.6) | 0.30 |
| AA | 14 | 107.8 (71.4-162.7) |
All polymorphisms were significantly associated with TAFI levels (P < 10−4).