Dosages of factor VIII coagulant activity (VIII:c) recommended in patients with von Willebrand disease treated with VIII–vWF concentrates
| Type of bleeding . | Dose (IU/kg) . | Number of infusions . | Target . |
|---|---|---|---|
| Major surgery | 40 -60 | Once a day | Maintain plasma VIII:c > 50 IU/dL until healing is complete, depending on the type of surgery |
| Minor surgery | 30 -50 | Once a day or every other day | VIII:c > 30 IU/dL until healing is complete, depending on the type of surgery |
| Dental extractions | 20 -30 | Single | VIII:c > 30 IU/dL for at least 12 hours |
| Spontaneous bleeding episodes | 20 -30 | Single | VIII:c > 30 IU/dL |
| Type of bleeding . | Dose (IU/kg) . | Number of infusions . | Target . |
|---|---|---|---|
| Major surgery | 40 -60 | Once a day | Maintain plasma VIII:c > 50 IU/dL until healing is complete, depending on the type of surgery |
| Minor surgery | 30 -50 | Once a day or every other day | VIII:c > 30 IU/dL until healing is complete, depending on the type of surgery |
| Dental extractions | 20 -30 | Single | VIII:c > 30 IU/dL for at least 12 hours |
| Spontaneous bleeding episodes | 20 -30 | Single | VIII:c > 30 IU/dL |
For concentrates labeled in terms of vWF:RCoF, the recommended doses for adults, the number of infusions, and the target plasma levels are the same as those for VIII:c.