Number of de novo acute myeloid leukemia case and control subjects, adjusted odds ratios, and 95% confidence intervals by cytogenetics for the NQO1 enzyme, using wild type as the reference
| Cytogenetics* . | Wild type . | Heterozygote + Homozygote . | ||||
|---|---|---|---|---|---|---|
| Case . | Control . | Case . | Control . | OR† . | 95% CI† . | |
| Normal | 83 | 177 | 65 | 85 | 1.71 | (1.09, 2.69) |
| Translocations: | 46 | 106 | 42 | 37 | 2.39 | (1.34, 4.27) |
| t(15;17) | 28 | 51 | 16 | 23 | 1.46 | (0.64, 3.36) |
| t(8;21) | 12 | 33 | 14 | 9 | 2.88 | (0.97, 8.57) |
| inv(16) | 6 | 22 | 12 | 5 | 8.13 | (1.43, 46.42) |
| 5q−/7q− | 11 | 21 | 11 | 16 | 1.57 | (0.38, 6.49) |
| Other abnormality | 53 | 90 | 28 | 48 | 1.05 | (0.58, 1.89) |
| Failed/not tested | 51 | 90 | 29 | 49 | 1.03 | (0.58, 1.82) |
| Cytogenetics* . | Wild type . | Heterozygote + Homozygote . | ||||
|---|---|---|---|---|---|---|
| Case . | Control . | Case . | Control . | OR† . | 95% CI† . | |
| Normal | 83 | 177 | 65 | 85 | 1.71 | (1.09, 2.69) |
| Translocations: | 46 | 106 | 42 | 37 | 2.39 | (1.34, 4.27) |
| t(15;17) | 28 | 51 | 16 | 23 | 1.46 | (0.64, 3.36) |
| t(8;21) | 12 | 33 | 14 | 9 | 2.88 | (0.97, 8.57) |
| inv(16) | 6 | 22 | 12 | 5 | 8.13 | (1.43, 46.42) |
| 5q−/7q− | 11 | 21 | 11 | 16 | 1.57 | (0.38, 6.49) |
| Other abnormality | 53 | 90 | 28 | 48 | 1.05 | (0.58, 1.89) |
| Failed/not tested | 51 | 90 | 29 | 49 | 1.03 | (0.58, 1.82) |
NQO1 indicates NAD(P)H:quinone oxidoreductase 1.
Translocations include t(15;17), t(8;21), or inv(16); 5q−/7q− includes −5/5q−/−7/7q−; other abnormality includes other clonal abnormalities not classified elsewhere.
Odds ratio were estimated by means of conditional logistic regression, adjusted for deprivation.