Number of case and control subjects, adjusted odds ratios, and 95% confidence intervals by diagnosis for the NQO1 enzyme, using wild type as the reference
| Diagnosis* . | Wild type† . | Heterozygote + Homozygote† . | ||||
|---|---|---|---|---|---|---|
| Case . | Control . | Case . | Control . | OR‡ . | 95% CI . | |
| Acute leukemia | 285 | 562 | 205 | 274 | 1.49 | (1.17, 1.89) |
| AML | 244 | 484 | 175 | 235 | 1.47 | (1.13, 1.90) |
| AML M0 | 14 | 27 | 7 | 10 | 1.39 | (0.41, 4.71) |
| AML M1 | 47 | 86 | 28 | 42 | 1.33 | (0.67, 2.63) |
| AML M2 | 49 | 110 | 47 | 53 | 2.01 | (1.17, 3.45) |
| AML M3 | 34 | 59 | 19 | 31 | 1.22 | (0.58, 2.53) |
| AML M4 | 40 | 77 | 31 | 43 | 1.29 | (0.70, 2.36) |
| AML M5 | 23 | 51 | 14 | 13 | 2.59 | (1.00, 6.71) |
| AML M6 | 12 | 24 | 6 | 8 | 1.42 | (0.34, 5.93) |
| AML M7 | 2 | 1 | 2 | 4 | 0.29 | (0.01, 6.50) |
| ALL | 36 | 73 | 29 | 35 | 1.93 | (0.96, 3.87) |
| ALL B | 22 | 50 | 24 | 28 | 2.20 | (0.99, 4.89) |
| ALL T | 8 | 13 | 3 | 3 | 1.50 | (0.19, 11.94) |
| Diagnosis* . | Wild type† . | Heterozygote + Homozygote† . | ||||
|---|---|---|---|---|---|---|
| Case . | Control . | Case . | Control . | OR‡ . | 95% CI . | |
| Acute leukemia | 285 | 562 | 205 | 274 | 1.49 | (1.17, 1.89) |
| AML | 244 | 484 | 175 | 235 | 1.47 | (1.13, 1.90) |
| AML M0 | 14 | 27 | 7 | 10 | 1.39 | (0.41, 4.71) |
| AML M1 | 47 | 86 | 28 | 42 | 1.33 | (0.67, 2.63) |
| AML M2 | 49 | 110 | 47 | 53 | 2.01 | (1.17, 3.45) |
| AML M3 | 34 | 59 | 19 | 31 | 1.22 | (0.58, 2.53) |
| AML M4 | 40 | 77 | 31 | 43 | 1.29 | (0.70, 2.36) |
| AML M5 | 23 | 51 | 14 | 13 | 2.59 | (1.00, 6.71) |
| AML M6 | 12 | 24 | 6 | 8 | 1.42 | (0.34, 5.93) |
| AML M7 | 2 | 1 | 2 | 4 | 0.29 | (0.01, 6.50) |
| ALL | 36 | 73 | 29 | 35 | 1.93 | (0.96, 3.87) |
| ALL B | 22 | 50 | 24 | 28 | 2.20 | (0.99, 4.89) |
| ALL T | 8 | 13 | 3 | 3 | 1.50 | (0.19, 11.94) |
NQO1 indicates NAD(P)H:quinone oxidoreductase 1; OR, odds ratio; CI, confidence interval; AML, acute myeloid leukemia; and ALL, acute lymphoblastic leukemia.
Four cases had a diagnosis of acute biphenotypic leukemia, and 2 cases had a diagnosis of unspecified acute leukemia.
Wild type showed high activity of NQO1 enzyme; heterozygote, low activity; and homozygote, no activity. Samples for 3 cases and 2 controls would not amplify.
Odds ratios were estimated by means of conditional logistic regression adjusted for deprivation.