Effects of CD45-ligation on antithrombin III–induced chemotaxis and deactivation
| . | Chemotaxis versus . | ||
|---|---|---|---|
| IL-8 [1 nM/L] . | fMLP [10 nM/L] . | AT III [1 U] . | |
| Medium | 2.080 ± 0.18 | 1.632 ± 0.20 | 1.374 ± 0.08 |
| CD45-Bra55 [5 μg/mL] | 1.469 ± 0.16 | 1.299 ± 0.11 | 1.103 ± 0.08 |
| CD45-Bra55 + Tyrphostin | 2.215 ± 0.123-150 | 1.367 ± 0.22 ns | 1.338 ± 0.043-150 |
| AT III [1 U] | 1.510 ± 0.07 | 1.119 ± 0.11 | 1.030 ± 0.04 |
| AT III + Tyrphostin | 1.904 ± 0.103-150 | 1.343 ± 0.133-150 | 1.194 ± 0.10 ns |
| CD45-Bra + AT III + Tyrphostin | 1.779 ± 0.14 | 1.367 ± 0.22 | 1.550 ± 0.26 |
| . | Chemotaxis versus . | ||
|---|---|---|---|
| IL-8 [1 nM/L] . | fMLP [10 nM/L] . | AT III [1 U] . | |
| Medium | 2.080 ± 0.18 | 1.632 ± 0.20 | 1.374 ± 0.08 |
| CD45-Bra55 [5 μg/mL] | 1.469 ± 0.16 | 1.299 ± 0.11 | 1.103 ± 0.08 |
| CD45-Bra55 + Tyrphostin | 2.215 ± 0.123-150 | 1.367 ± 0.22 ns | 1.338 ± 0.043-150 |
| AT III [1 U] | 1.510 ± 0.07 | 1.119 ± 0.11 | 1.030 ± 0.04 |
| AT III + Tyrphostin | 1.904 ± 0.103-150 | 1.343 ± 0.133-150 | 1.194 ± 0.10 ns |
| CD45-Bra + AT III + Tyrphostin | 1.779 ± 0.14 | 1.367 ± 0.22 | 1.550 ± 0.26 |
Mann-Whitney test after Kruskal-Wallis analysis of variance (P < .01); n = 5.
For abbreviations, see Table 2.
P < .01.