Randomized controlled trials investigating the association between perioperative allogeneic blood transfusion and postoperative bacterial infection
Study . | Total sample size3-150 . | Design . | RBC product given to the treatment arm . | RBC product given to the control arm . | Overall percentage having transfusion3-151 . | Overall percentage developing postoperative infection3-151 . |
---|---|---|---|---|---|---|
Jensen et al3 | 197 | ?Single blind | Allogeneic whole blood | WBC-reduced allogeneic whole blood (filtered after storage) | 52.8 | 8.1 |
Heiss et al4 | 120 | Unblinded | BC-reduced allogeneic RBCs | Autologous RBCs | 75.0 | 20.0 |
Busch et al23 | 470 | Unblinded | BC-reduced allogeneic RBCs | Autologous whole blood | 59.0 | 26.0 |
Houbiers et al22 | 697 | Single blind3-152 | BC-reduced allogeneic RBCs | WBC-reduced, BC-reduced allogeneic RBCs (filtered before storage) | 64.0 | 33.4 |
Jensen et al5 | 589 | Single blind3-152 | BC-reduced allogeneic RBCs | WBC-reduced, BC-reduced allogeneic RBCs (filtered after storage) | 44.1 | 17.5 |
van de Watering et al6 | 909 | Single blind3-152 | BC-reduced allogeneic RBCs | WBC-reduced, BC-reduced allogeneic RBCs (filtered before [n = 302] or after [n = 302] storage) | 94.8 | 19.3 |
Tartter et al7 | 221 | Unblinded | Allogeneic RBCs | WBC-reduced allogeneic RBCs | 26.7 | 16.7 |
Study . | Total sample size3-150 . | Design . | RBC product given to the treatment arm . | RBC product given to the control arm . | Overall percentage having transfusion3-151 . | Overall percentage developing postoperative infection3-151 . |
---|---|---|---|---|---|---|
Jensen et al3 | 197 | ?Single blind | Allogeneic whole blood | WBC-reduced allogeneic whole blood (filtered after storage) | 52.8 | 8.1 |
Heiss et al4 | 120 | Unblinded | BC-reduced allogeneic RBCs | Autologous RBCs | 75.0 | 20.0 |
Busch et al23 | 470 | Unblinded | BC-reduced allogeneic RBCs | Autologous whole blood | 59.0 | 26.0 |
Houbiers et al22 | 697 | Single blind3-152 | BC-reduced allogeneic RBCs | WBC-reduced, BC-reduced allogeneic RBCs (filtered before storage) | 64.0 | 33.4 |
Jensen et al5 | 589 | Single blind3-152 | BC-reduced allogeneic RBCs | WBC-reduced, BC-reduced allogeneic RBCs (filtered after storage) | 44.1 | 17.5 |
van de Watering et al6 | 909 | Single blind3-152 | BC-reduced allogeneic RBCs | WBC-reduced, BC-reduced allogeneic RBCs (filtered before [n = 302] or after [n = 302] storage) | 94.8 | 19.3 |
Tartter et al7 | 221 | Unblinded | Allogeneic RBCs | WBC-reduced allogeneic RBCs | 26.7 | 16.7 |
RBC indicates red blood cell; WBC, white blood cell; BC, buffy coat.
Used in the analysis of postoperative bacterial infection after patient exclusions and withdrawals.
In both the treatment and control arms combined.
Investigators making diagnoses of postoperative infection were blinded to the treatment allocations.