Table 3.

Randomized controlled trials investigating the association between perioperative allogeneic blood transfusion and postoperative bacterial infection

StudyTotal sample size3-150DesignRBC product given to the treatment armRBC product given to the control armOverall percentage having transfusion3-151Overall percentage developing postoperative infection3-151
Jensen et al3 197 ?Single blind Allogeneic whole blood WBC-reduced allogeneic whole blood (filtered after storage) 52.8 8.1  
Heiss et al4 120 Unblinded BC-reduced allogeneic RBCs Autologous RBCs 75.0 20.0  
Busch et al23 470 Unblinded BC-reduced allogeneic RBCs Autologous whole blood 59.0 26.0  
Houbiers et al22 697 Single blind3-152 BC-reduced allogeneic RBCs WBC-reduced, BC-reduced allogeneic RBCs (filtered before storage) 64.0 33.4  
Jensen et al5 589 Single blind3-152 BC-reduced allogeneic RBCs WBC-reduced, BC-reduced allogeneic RBCs (filtered after storage) 44.1 17.5  
van de Watering et al6 909 Single blind3-152 BC-reduced allogeneic RBCs WBC-reduced, BC-reduced allogeneic RBCs (filtered before [n = 302] or after
[n = 302] storage) 
94.8 19.3  
Tartter et al7 221 Unblinded Allogeneic RBCs WBC-reduced allogeneic RBCs 26.7 16.7 
StudyTotal sample size3-150DesignRBC product given to the treatment armRBC product given to the control armOverall percentage having transfusion3-151Overall percentage developing postoperative infection3-151
Jensen et al3 197 ?Single blind Allogeneic whole blood WBC-reduced allogeneic whole blood (filtered after storage) 52.8 8.1  
Heiss et al4 120 Unblinded BC-reduced allogeneic RBCs Autologous RBCs 75.0 20.0  
Busch et al23 470 Unblinded BC-reduced allogeneic RBCs Autologous whole blood 59.0 26.0  
Houbiers et al22 697 Single blind3-152 BC-reduced allogeneic RBCs WBC-reduced, BC-reduced allogeneic RBCs (filtered before storage) 64.0 33.4  
Jensen et al5 589 Single blind3-152 BC-reduced allogeneic RBCs WBC-reduced, BC-reduced allogeneic RBCs (filtered after storage) 44.1 17.5  
van de Watering et al6 909 Single blind3-152 BC-reduced allogeneic RBCs WBC-reduced, BC-reduced allogeneic RBCs (filtered before [n = 302] or after
[n = 302] storage) 
94.8 19.3  
Tartter et al7 221 Unblinded Allogeneic RBCs WBC-reduced allogeneic RBCs 26.7 16.7 

RBC indicates red blood cell; WBC, white blood cell; BC, buffy coat.

F3-150

Used in the analysis of postoperative bacterial infection after patient exclusions and withdrawals.

F3-151

In both the treatment and control arms combined.

F3-152

Investigators making diagnoses of postoperative infection were blinded to the treatment allocations.

Close Modal

or Create an Account

Close Modal
Close Modal