Table 2. Effect of buffy-coat reduction... | American Society of Hematology

Table 2.

Effect of buffy-coat reduction in decreasing allogeneic blood transfusion–induced tumor growth in New Zealand White rabbits with established tumors^*

Red cell transfusion received	Sample size	Number of pulmonary tumor nodules (median ± SE)
Allogeneic, unmodified (stored)	20	74.0 ± 8.7
Allogeneic, buffy coat reduced before storage^†	19	34.0 ± 7.0
Allogeneic, WBC reduced before storage^‡	20	23.5 ± 1.8
Control group (no transfusion)	16	21.5 ± 2.5

Red cell transfusion received	Sample size	Number of pulmonary tumor nodules (median ± SE)
Allogeneic, unmodified (stored)	20	74.0 ± 8.7
Allogeneic, buffy coat reduced before storage^†	19	34.0 ± 7.0
Allogeneic, WBC reduced before storage^‡	20	23.5 ± 1.8
Control group (no transfusion)	16	21.5 ± 2.5

WBC indicates white blood cell.

Modified from Blajchman.30

Mean decrease in WBC dose of 76% (similar to the buffy-coat reduction method used in the RCTs4-6,22 23 reported from western Europe).

Mean decrease in WBC dose of 99.7%.