Peripheral quantitative computer tomography of femurs from transplant recipients compared to untreated controls showing maintenance of more normal bone structures
| . | Total density . | Cortical density . | Cortical thickness . | Periosteal circumference . |
|---|---|---|---|---|
| Males | ||||
| +/+ | 0.497 ± 0.021 | 0.649 ± 0.025 | 0.331 ± 0.012 | 5.449 ± 0.041 |
| MPS VII | 0.561 ± 0.011 | 0.676 ± 0.015 | 0.437 ± 0.005 | 6.094 ± 0.243 |
| 3xBMT | 0.429 ± 0.032 | 0.594 ± 0.040 | 0.315 ± 0.044 | 5.609 ± 0.190 |
| MPS VII vs +/+ | P = .001 (SD) | P = .087 (ND) | P < .001 (SD) | P < .001 (SD) |
| 3xBMT vs +/+ | P = .043 (SD) | NA | P = .598 (ND) | P = .279 (ND) |
| 3xBMT vs MPS VII | P = .014 (SD) | NA | P = .039 (SD) | P = .024 (SD) |
| Females | ||||
| +/+ | 0.509 ± 0.017 | 0.638 ± 0.020 | 0.319 ± 0.012 | 4.845 ± 0.096 |
| MPS VII | 0.568 ± 0.022 | 0.686 ± 0.008 | 0.412 ± 0.041 | 5.911 ± 0.143 |
| 3xBMT | 0.466 ± 0.028 | 0.632 ± 0.013 | 0.303 ± 0.021 | 5.492 ± 0.310 |
| MPS VII vs +/+ | P = .020 (SD) | P = .004 (SD) | P = .055 (ND) | P = .001 (SD) |
| 3xBMT vs +/+ | P = .046 (SD) | P = .628 (ND) | NA | P = .021 (SD) |
| 3xBMT vs MPS VII | P = .003 (SD) | P = .001 (SD) | NA | P = .069 (ND) |
| . | Total density . | Cortical density . | Cortical thickness . | Periosteal circumference . |
|---|---|---|---|---|
| Males | ||||
| +/+ | 0.497 ± 0.021 | 0.649 ± 0.025 | 0.331 ± 0.012 | 5.449 ± 0.041 |
| MPS VII | 0.561 ± 0.011 | 0.676 ± 0.015 | 0.437 ± 0.005 | 6.094 ± 0.243 |
| 3xBMT | 0.429 ± 0.032 | 0.594 ± 0.040 | 0.315 ± 0.044 | 5.609 ± 0.190 |
| MPS VII vs +/+ | P = .001 (SD) | P = .087 (ND) | P < .001 (SD) | P < .001 (SD) |
| 3xBMT vs +/+ | P = .043 (SD) | NA | P = .598 (ND) | P = .279 (ND) |
| 3xBMT vs MPS VII | P = .014 (SD) | NA | P = .039 (SD) | P = .024 (SD) |
| Females | ||||
| +/+ | 0.509 ± 0.017 | 0.638 ± 0.020 | 0.319 ± 0.012 | 4.845 ± 0.096 |
| MPS VII | 0.568 ± 0.022 | 0.686 ± 0.008 | 0.412 ± 0.041 | 5.911 ± 0.143 |
| 3xBMT | 0.466 ± 0.028 | 0.632 ± 0.013 | 0.303 ± 0.021 | 5.492 ± 0.310 |
| MPS VII vs +/+ | P = .020 (SD) | P = .004 (SD) | P = .055 (ND) | P = .001 (SD) |
| 3xBMT vs +/+ | P = .046 (SD) | P = .628 (ND) | NA | P = .021 (SD) |
| 3xBMT vs MPS VII | P = .003 (SD) | P = .001 (SD) | NA | P = .069 (ND) |
Femurs were scanned using a Stratec XCT 960M densitometer. The mean ± SD of values assigned by the densitometry for bone structural parameters are shown (n = 3-5 animals per group). Densitometry values were compared between treatment groups using Student t test to determine significant differences, and the resulting P values are also shown.
MPS VII indicates mucopolysaccharidosis type VII; BMT, bone marrow transplantation; SD, significant difference (P < .05); ND, no significant difference; NA, not applicable, no significant difference between controls. Shading indicates fully normalized bone parameter.