Depletion of thymic progeny via mAb treatment increases LN-derived progeny in thymus-bearing hosts after BMT
| Reconstituted cell type . | Treatment . | ||
|---|---|---|---|
| Sham (× 106) . | mAb (× 106) . | Pvalue . | |
| BM type (Thy 1.2) | 33.0 ± 2.2 | 0.22 ± 0.1 | .001 |
| LN derived (Thy 1.1) | 3.3 ± 0.5 | 6.7 ± 1.3 | .03 |
| Reconstituted cell type . | Treatment . | ||
|---|---|---|---|
| Sham (× 106) . | mAb (× 106) . | Pvalue . | |
| BM type (Thy 1.2) | 33.0 ± 2.2 | 0.22 ± 0.1 | .001 |
| LN derived (Thy 1.1) | 3.3 ± 0.5 | 6.7 ± 1.3 | .03 |
C57BL/6 mice underwent BMT as described in “Materials and methods.” Experimental animals received anti-Thy 1.2 mAb 0.4 mL intraperitoneally weekly × 4 beginning on day +7 after BMT (n = 5) and sham mice received a carrier over the same time period (n = 5). Mice were sacrificed and splenic populations were analyzed 5 weeks after BMT.