Table 1. Clinicopathologic features of... | American Society of Hematology

Table 1.

Clinicopathologic features of BCR/ABL-induced CML-like disease with cytokine-deficient donor/recipient mice

Genotype^*		Median survival (d)	PB WBC (×10³/μL ± SE)	Differential^†							Spleen wt (g ± SE)^‡	Liver^1-153	Lungs^1-155
Donor	Recipient	Median survival (d)	PB WBC (×10³/μL ± SE)	N	Meta	Pro	Mo	Ery	Ly	Bl	Spleen wt (g ± SE)^‡	Liver^1-153	Lungs^1-155
WT	WT	22	295 ± 59	54	16	3	11	7	7	2	0.91 ± 0.06	+	+
Il-3^−/−	WT	21	110 ± 15 (P = .022)^1-154	50	8	4	8	19	9	2	0.85 ± 0.05	+	+
WT	Il-3^−/−	22	262 ± 93	63	12	2	11	6	4	2	0.87 ± 0.04	+	+
Il-3^−/−	Il-3^−/−	20 (P = .01)#	101 ± 18 (P = .008)^1-154	31	11	1	48	6	3	1	0.84 ± 0.05	+	+
Gm-csf^−/−	WT	23	235 ± 45	46	12	4	9	8	5	3	0.69 ± 0.09	+	+
WT	Gm-csf^−/−	23	232 ± 87	56	12	6	7	8	8	3	0.95 ± 0.06	+	+
Gm-csf^−/−	Gm-csf^−/−	27 (P = .002)#	226 ± 40	55	16	3	16	5	5	1	0.80 ± 0.06	+	+
Il-3^−/−Gm-csf^−/−	Il-3^−/−Gm-csf^−/−	16 (P = .005)#	334 ± 115	44	13	3	27	11	3	1	0.75 ± 0.08	+	+

Genotype^*		Median survival (d)	PB WBC (×10³/μL ± SE)	Differential^†							Spleen wt (g ± SE)^‡	Liver^1-153	Lungs^1-155
Donor	Recipient	Median survival (d)	PB WBC (×10³/μL ± SE)	N	Meta	Pro	Mo	Ery	Ly	Bl	Spleen wt (g ± SE)^‡	Liver^1-153	Lungs^1-155
WT	WT	22	295 ± 59	54	16	3	11	7	7	2	0.91 ± 0.06	+	+
Il-3^−/−	WT	21	110 ± 15 (P = .022)^1-154	50	8	4	8	19	9	2	0.85 ± 0.05	+	+
WT	Il-3^−/−	22	262 ± 93	63	12	2	11	6	4	2	0.87 ± 0.04	+	+
Il-3^−/−	Il-3^−/−	20 (P = .01)#	101 ± 18 (P = .008)^1-154	31	11	1	48	6	3	1	0.84 ± 0.05	+	+
Gm-csf^−/−	WT	23	235 ± 45	46	12	4	9	8	5	3	0.69 ± 0.09	+	+
WT	Gm-csf^−/−	23	232 ± 87	56	12	6	7	8	8	3	0.95 ± 0.06	+	+
Gm-csf^−/−	Gm-csf^−/−	27 (P = .002)#	226 ± 40	55	16	3	16	5	5	1	0.80 ± 0.06	+	+
Il-3^−/−Gm-csf^−/−	Il-3^−/−Gm-csf^−/−	16 (P = .005)#	334 ± 115	44	13	3	27	11	3	1	0.75 ± 0.08	+	+

WT indicates wild-type.

All mice are Balb/c.

†

Mean % of: N, neutrophils; Meta, metamyelocytes; Pro, promyelocytes; Mo, monocytes and macrophages; Ery, nucleated erythroid cells; Ly, lymphocytes; Bl, blasts.

‡

None were significantly different from WT to WT (P ≥ .05, unpaired t test).

F1-153

Hepatomegaly with extramedullary hematopoiesis, neutrophil infiltration, and macrophage aggregates.

F1-155

Intra-alveolar myeloid cell infiltration with hemorrhages.

F1-154

Significantly different from WT to WT, unpaired t test.

#Significantly different from WT to WT, Mantel-Cox test.

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