Peripheral blood counts in GM−/−IL3−/− mice
| Genotype . | RBC (×106) . | Platelets (×103) . | WBC (×103) . | Eosinophils (×103) . | Lymphocytes (×103) . | Neutrophils (×103) . | Monocytes (×103) . |
|---|---|---|---|---|---|---|---|
| +/+ | 9.5 ± 1.2 | 1054 ± 281 | 6.3 ± 2.1 | 0.08 ± 0.03 | 5.1 ± 1.6 | 0.98 ± 0.41 | 0.14 ± 0.04 |
| GM−/−IL3−/− | 9.6 ± 0.4 | 1074 ± 209 | 8.1 ± 1.9 | 0.32* ± 0.10 | 6.3 ± 1.5 | 1.26 ± 0.39 | 0.19 ± 0.08 |
| GM−/− | 9.2 ± 0.2 | 1008 ± 363 | 6.9 ± 2.2 | 0.09 ± 0.04 | 5.5 ± 1.7 | 1.14 ± 0.52 | 0.15 ± 0.08 |
| IL3−/− | 9.9 ± 0.4 | 1113 ± 126 | 8.0 ± 1.1 | 0.12 ± 0.04 | 6.5 ± 0.8 | 1.20 ± 0.32 | 0.19 ± 0.06 |
| βc−/−GM−/−IL3−/− | 9.7 ± 0.4 | 1197 ± 135 | 5.11-164 ± 1.4 | 0.02† ± 0.02 | 4.11-153 ± 1.2 | 0.89 ± 0.21 | 0.12 ± 0.05 |
| Genotype . | RBC (×106) . | Platelets (×103) . | WBC (×103) . | Eosinophils (×103) . | Lymphocytes (×103) . | Neutrophils (×103) . | Monocytes (×103) . |
|---|---|---|---|---|---|---|---|
| +/+ | 9.5 ± 1.2 | 1054 ± 281 | 6.3 ± 2.1 | 0.08 ± 0.03 | 5.1 ± 1.6 | 0.98 ± 0.41 | 0.14 ± 0.04 |
| GM−/−IL3−/− | 9.6 ± 0.4 | 1074 ± 209 | 8.1 ± 1.9 | 0.32* ± 0.10 | 6.3 ± 1.5 | 1.26 ± 0.39 | 0.19 ± 0.08 |
| GM−/− | 9.2 ± 0.2 | 1008 ± 363 | 6.9 ± 2.2 | 0.09 ± 0.04 | 5.5 ± 1.7 | 1.14 ± 0.52 | 0.15 ± 0.08 |
| IL3−/− | 9.9 ± 0.4 | 1113 ± 126 | 8.0 ± 1.1 | 0.12 ± 0.04 | 6.5 ± 0.8 | 1.20 ± 0.32 | 0.19 ± 0.06 |
| βc−/−GM−/−IL3−/− | 9.7 ± 0.4 | 1197 ± 135 | 5.11-164 ± 1.4 | 0.02† ± 0.02 | 4.11-153 ± 1.2 | 0.89 ± 0.21 | 0.12 ± 0.05 |
Results (mean ± SD) of a 300 cell count differential for 10 mice (ages 2-5 months) per group.
GM−/−IL3−/− versus +/+, GM−/−, IL3−/−, and βc−/−GM−/−IL3−/−, P = .0001, .0001, .0002, and .0001.
βc−/−GM−/−IL3−/− versus GM−/−IL3−/− and +/+,P = .0001.
βc−/−GM−/−IL3−/− versus GM−/−IL3−/−, P = .0017.
βc−/−GM−/−IL3−/− versus GM−/−IL3−/−, P = .0025.