Table 4. Risk of MI according to... | American Society of Hematology

Table 4.

Risk of MI according to presence of Kozak C allele: analysis stratified by cardiovascular risk factors

Risk factor	MI cases (n = 78)		Controls (n = 384)		OR^4-150	(95% CI)^4-150	P value for interaction
Risk factor	T/C or C/C	T/T	T/C or C/C	T/T	OR^4-150	(95% CI)^4-150	P value for interaction
Overall	11	67	91	293	0.53	(0.27-1.05)
Current smoking
No	4	20	74	231	0.62	(0.21-1.88)	0.88
Yes	7	47	17	62	0.55	(0.21-1.46)
Obesity
BMI < 27.3 kg/m²	2	32	66	213	0.20	(0.05-0.87)	0.09
BMI ≥ 27.3 kg/m²	9	35	25	77	0.81	(0.33-1.94)
Hypertension, diabetes, or hypercholesterolemia
No	2	28	70	218	0.22	(0.05-0.96)	0.10
Yes	9	39	21	75	0.83	(0.35-1.99)
Early family history of MI in first degree relative
No	7	43	75	249	0.55	(0.24-1.26)	0.88
Yes	4	22	14	39	0.43	(0.11-1.62)
Plasma homocysteine
<12.6 mg/dL	4	34	70	216	0.36	(0.12-1.05)	0.21
≥12.6 mg/dL	7	33	19	74	0.92	(0.34-2.48)
Factor V or prothrombin mutations
No	10	56	88	272	0.55	(0.27-1.13)	0.93
Yes	1	11	3	18	0.61	(0.05-6.88)
HPA-2b allele
No	57	10	242	79	0.54	(0.26-1.10)	0.87
Yes	1	10	12	51	0.45	(0.05-3.89)

Risk factor	MI cases (n = 78)		Controls (n = 384)		OR^4-150	(95% CI)^4-150	P value for interaction
Risk factor	T/C or C/C	T/T	T/C or C/C	T/T	OR^4-150	(95% CI)^4-150	P value for interaction
Overall	11	67	91	293	0.53	(0.27-1.05)
Current smoking
No	4	20	74	231	0.62	(0.21-1.88)	0.88
Yes	7	47	17	62	0.55	(0.21-1.46)
Obesity
BMI < 27.3 kg/m²	2	32	66	213	0.20	(0.05-0.87)	0.09
BMI ≥ 27.3 kg/m²	9	35	25	77	0.81	(0.33-1.94)
Hypertension, diabetes, or hypercholesterolemia
No	2	28	70	218	0.22	(0.05-0.96)	0.10
Yes	9	39	21	75	0.83	(0.35-1.99)
Early family history of MI in first degree relative
No	7	43	75	249	0.55	(0.24-1.26)	0.88
Yes	4	22	14	39	0.43	(0.11-1.62)
Plasma homocysteine
<12.6 mg/dL	4	34	70	216	0.36	(0.12-1.05)	0.21
≥12.6 mg/dL	7	33	19	74	0.92	(0.34-2.48)
Factor V or prothrombin mutations
No	10	56	88	272	0.55	(0.27-1.13)	0.93
Yes	1	11	3	18	0.61	(0.05-6.88)
HPA-2b allele
No	57	10	242	79	0.54	(0.26-1.10)	0.87
Yes	1	10	12	51	0.45	(0.05-3.89)

MI indicates myocardial infarction; OR, odds ratio; CI, confidence interval; BMI, body mass index.

OR and 95% CI calculated for presence of C allele (homozygous or heterozygous) compared with TT genotype, and adjusted for age.