Colony forming assays of human bone marrow–derived CD34+ cells from patients with cyclic neutropenia and healthy volunteers
| . | Controls (n = 10) . | Patients (n = 6) . | Patients on G-CSF (n = 3) . |
|---|---|---|---|
| CFU-HPP | 70 ± 10 | 94 ± 12* | 77 ± 16 |
| CFU-GM early | 44 ± 8 | 10 ± 2* | 28 ± 12* |
| CFU-GM late | 16 ± 2 | 10 ± 2* | 16 ± 6 |
| Ratio:CFU-HPP CFU-GM early | 1.6 | 9.8 | 2.8 |
| Ratio: CFU-HPP CFU-GM late | 4.4 | 9.0 | 4.8 |
| . | Controls (n = 10) . | Patients (n = 6) . | Patients on G-CSF (n = 3) . |
|---|---|---|---|
| CFU-HPP | 70 ± 10 | 94 ± 12* | 77 ± 16 |
| CFU-GM early | 44 ± 8 | 10 ± 2* | 28 ± 12* |
| CFU-GM late | 16 ± 2 | 10 ± 2* | 16 ± 6 |
| Ratio:CFU-HPP CFU-GM early | 1.6 | 9.8 | 2.8 |
| Ratio: CFU-HPP CFU-GM late | 4.4 | 9.0 | 4.8 |
Data represent mean values of triplicate experiments ± SD.
When compared with control group, the statistical difference withP value < .02 was observed.
G-CSF indicates granulocyte colony-stimulating factor; CFU-HPP, high proliferative potential colony forming cell; CFU-GM, granulocyte macrophage colony-forming unit.